Cross-whisker adaptation of neurons in the rat barrel cortex
Cross-whisker adaptation of neurons in the rat barrel cortex
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DOI：
10.1523/jneurosci.4056-06.2006
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发表时间：
2006-12-20
影响因子：
5.3
通讯作者：
Lampl, Ilan
中科院分区：
文献类型：
--
作者：
Katz, Yonatan;Heiss, Jaime E.;Lampl, Ilan
桶状皮层和丘脑中的神经元优先对一根胡须（主胡须）的刺激做出反应，而对几个相邻胡须的刺激反应较弱。与丘脑细胞不同，皮质神经元逐渐适应胡须的重复刺激。皮层适应是否特定于受刺激的胡须尚不清楚。这项细胞内研究的目的是确定皮层细胞对相邻胡须刺激的反应是否会受到先前由主胡须刺激引起的适应的影响，反之亦然。使用高频刺激会引起皮质的大量适应，而丘脑的适应则要少得多，我们表明，施加到一根胡须的一系列刺激所引起的皮质适应不会影响对相邻胡须的后续刺激的突触反应。我们的数据表明内在机制不参与皮质适应。在相同条件下获得的丘脑记录表明，丘脑中没有产生相邻的胡须反应，这表明观察到的胡须特异性适应是由不同的丘脑输入或皮质整合引起的。
Neurons in the barrel cortex and the thalamus respond preferentially to stimulation of one whisker ( the principal whisker) and weakly to several adjacent whiskers. Cortical neurons, unlike thalamic cells, gradually adapt to repeated whisker stimulations. Whether cortical adaptation is specific to the stimulated whisker is not known. The aim of this intracellular study was to determine whether the response of a cortical cell to stimulation of an adjacent whisker would be affected by previous adaptation induced by stimulation of the principal whisker and vice versa. Using a high-frequency stimulation that causes substantial adaptation in the cortex and much less adaptation in the thalamus, we show that cortical adaptation evoked by a train of stimuli applied to one whisker does not affect the synaptic response to subsequent stimulation of a neighboring whisker. Our data indicate that intrinsic mechanisms are not involved in cortical adaptation. Thalamic recordings obtained under the same conditions demonstrated that an adjacent whisker response was not generated in the thalamus, indicating that the observed whisker- specific adaptation results from diverging thalamic inputs or from cortical integration.