Cardiovascular indices of peripheral and central sympathetic activation
Cardiovascular indices of peripheral and central sympathetic activation
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DOI：
10.1097/00006842-200109000-00012
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Langewitz, W
中科院分区：
文献类型：
--
作者：
Sch채chinger, H;Weinbacher, M;Langewitz, W
目的：交感神经系统（SNS）的一些参数已被用于心血管心理生理学。本研究的目的是描述的模式和冗余的一组SNS参数在外周引起的心脏交感神经激活和中枢SNS控制的反射调制的变化。射血前期（PEP）被评估为外周交感神经激活的标志物。低频血压变异性（BPV）被评估为中枢SNS控制的估计值。研究方法：分别使用肾上腺素和盐酸艾司洛尔（β（1）-阻滞）实现外周β-交感神经刺激和阻滞。分别用去甲肾上腺素和硝普钠加载和卸载动脉压力感受器引起中枢SNS输出的变化。这项在24名健康男性中进行的单盲、交叉研究还包括两个安慰剂对照期。PEP来源于阻抗心动图，并根据心率进行单独调整。BPV是通过心跳到心跳心率和收缩压（Finapres系统）数据的功率谱分析计算的。结果：肾上腺素输注期间PEP降低（-40.1 +/- 3.8 ms，p < .0001），艾司洛尔输注期间PEP升高（+6.6 +/- 3.5 ms，p = .05）。在硝普钠激活中枢SNS后PEP缩短（-16.8 +/-2.9 ms，p < 0.0001）。在输注硝普钠期间，低频范围（0.07-0.14 Hz，Mayer波）的SyrinBPV增加（+0.44 +/- 0.19 In mm Hg-2，p = 0.03），在输注去甲肾上腺素期间降低（-0.67 +/- 0.13 In mm Hg-2，p < 0.0001）。低频BPV在肾上腺素或艾司洛尔输注期间没有显著变化。结论：我们的数据提供了可分离的外周和中枢交感神经反应成分的经验证据。低频BPV和PEP的联合报告提供了关于中枢SNS控制和交感神经心脏激活水平的独特信息。
Objective: A number of sympathetic nervous system (SNS) parameters have been used in cardiovascular psychophysiology. This study aimed to describe the pattern and redundancy of a set of SNS parameters during peripherally induced changes of cardiac sympathetic activation and reflex modulation of central SNS control. Preejection period (PEP) was assessed as a marker of peripheral sympathetic activation. Low-frequency blood pressure variability (BPV) was assessed as an estimate of central SNS control. Methods: Peripheral beta -sympathetic stimulation and blockade were achieved with epinephrine and esmolol hydrochloride (beta (1)-blockade), respectively. Changes in central SNS output were induced by loading and unloading arterial baroreceptors with norepinephrine and nitroprusside sodium, respectively. This single-blinded, crossover study in 24 healthy men also included two placebo control periods. PEP was derived from impedance cardiography and adjusted individually for heart rate. BPV was calculated by power spectral analyses of beat-to-beat heart rate and systolic blood pressure (Finapres system) data. Results: PEP decreased during epinephrine infusion (-40.1 +/- 3.8 ms, p < .0001) and increased during esmolol infusion (+6.6 +/- 3.5 ms, p = .05). PEP was shortened after central SNS activation by nitroprusside (-16.8 +/- 2.9 ms, p < 0.0001). Systolic BPV in the low-frequency range (0.07-0.14 Hz, Mayer waves) increased during nitroprusside infusion (+0.44 +/- 0.19 In mm Hg-2, p = .03) and decreased during norepinephrine infusion (-0.67 +/- 0.13 In mm Hg-2, p < 0.0001). Low-frequency BPV did not change significantly during epinephrine or esmolol infusion. Conclusions: Our data provide empirical evidence of separable peripheral and central sympathetic response components. The combined report of low-frequency BPV and PEP gives distinct information on both central SNS control and the level of sympathetic cardiac activation achieved.