Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
Association between the brief inventory of neurocognitive impairment (BINI) and objective cognitive testing among persons with opioid use disorders in drug treatment
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DOI：
10.1080/10550887.2020.1831129
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发表时间：
2020-10-15
影响因子：
2.3
通讯作者：
Gunstad, John
中科院分区：
文献类型：
--
作者：
Copenhaver, Michael M.;Sanborn, Victoria;Gunstad, John
本研究探讨了参与药物治疗并稳定接受美沙酮维持治疗（MMT）的患者的主观认知功能障碍与客观测试表现之间的相关性。共有177名参与者完成了自我报告的神经认知障碍简要清单（BINI）和NIH神经功能缺损测试组合。在神经认知功能障碍的受试者中，所有BINI分量表的得分与NIH量表的客观表现呈负相关（BINI总体r =-0.26，p = 0.01; BINI分量表范围为-0.22至-0.32，allp < 0.03）。使用截止分数，结果显示在BINI学习子量表上得分高于截止分数的参与者在NIH量表上表现出客观神经认知功能障碍的显著证据（65% vs. 35%;chi（2）= 6.57，p = 0.02），表明可能的临床效用。未来的研究需要确定使用BINI告知具有特定神经认知特征的患者的适应性以优化治疗结果的可行性。
The current study examined the association between subjective cognitive dysfunction and objective test performance in persons enrolled in drug treatment and stabilized on methadone maintenance therapy (MMT). A total of 177 participants completed the self-reported brief inventory of neurocognitive impairment (BINI) and NIH Toolbox test battery. In participants with neurocognitive dysfunction, scores on all BINI subscales were negatively associated with objective performance on the NIH Toolbox (BINI Global r = -0.26,p = 0.01; BINI Subscales ranging -0.22 to -0.32, allp's < 0.03). Using cutoff scores, results showed participants who scored above the cutoff on the BINI Learning subscale demonstrated significant evidence of objective neurocognitive dysfunction on the NIH Toolbox (65% vs. 35%;chi(2)= 6.57,p = 0.02), suggesting possible clinical utility. Future studies are needed to determine the feasibility of using the BINI to inform the accommodation of patients with specific neurocognitive profiles to optimize treatment outcomes.