No association between apolipoprotein E polymorphisms and general cognitive ability in children
No association between apolipoprotein E polymorphisms and general cognitive ability in children
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DOI：
10.1016/s0304-3940(00)01789-4
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发表时间：
2001-02-16
影响因子：
2.5
通讯作者：
Owen, MJ
中科院分区：
文献类型：
--
作者：
Turic, D;Fisher, PJ;Owen, MJ
本研究探讨了编码载脂蛋白E（ApoE）的基因变异是影响一般认知能力（g）的一个因素这一假设。对101名高g和101名平均g儿童的病例对照样本进行了ApoE基因型和该基因转录调控区的两种变异（Th 1/E47 cs和-491AT）的评分。没有证据表明这些多态性和g之间的关联被发现。我们的结论是，在这些位点的变化是不是一个因素，在健康人群中的一般认知能力具有可测量的影响。(C)Elsevier Science爱尔兰有限公司出版。
In this work we explored the hypothesis that variation in the gene encoding apolipoprotein E (ApoE) is a factor modifying general cognitive ability (g), A case control sample of 101 high g and 101 average g children was scored for ApoE genotypes and two variants in the transcriptional regulatory region of the gene (Th1/E47cs and -491 AT). No evidence of association between these polymorphisms and g was found. We conclude that variation at these loci is not a factor with a measurable impact on general cognitive ability in the healthy population. (C) 2001 Published by Elsevier Science Ireland Ltd.