Successful autologous peripheral blood stem cell transplantation in primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
Successful autologous peripheral blood stem cell transplantation in primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma.
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成功进行自体外周血干细胞移植治疗原发性皮肤侵袭性表皮性 CD8 T 细胞淋巴瘤。
DOI：
10.1111/ddg.13084
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Nakama T.
中科院分区：
文献类型：
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作者：
Saruta H;Ohata C;Oku E;Natsuaki Y;Ohshima K;Nagafuji K;Nakama T.
原发性皮肤侵袭性亲表皮性CD 8 + T细胞淋巴瘤是一种罕见的细胞毒性淋巴瘤，临床表现为侵袭性和预后差。尽管干细胞移植（SCT）能有效提高高级别淋巴瘤患者的总体生存率，但只有少数PCAETCL患者接受了SCT，文献报道仅8例[1-5]。1例38岁男性患者，全身多处溃疡性肉芽肿性病变，病史1年。他的病情在前一个月迅速恶化。他的病史是原发性醛固酮增多症。体格检查显示覆盖全身的各种大小（直径≤ 15 cm）局限性溃疡（图1 a）。实验室检查显示白色血细胞计数升高至16，300/μ L（中性粒细胞
Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma (PCAETCL) is a rare cytotoxic lymphoma marked by an aggressive clinical course and poor prognosis. Although stem cell transplantation (SCT) effectively improves the overall survival rate of patients with high-grade lymphomas, only a small number of patients with PCAETCL have undergone SCT, with merely eight cases reported in the literature [1–5].A 38-year-old man presented with a one-year history of multiple ulcerated erythematous lesions across his entire body. His condition had rapidly deteriorated over the previous month. His medical history was remarkable for primary hyperaldosteronism. Physical examination revealed circumscribed ulcers of various sizes (≤ 15 cm in diameter) covering his entire body (Figure 1 a). Laboratory tests showed an elevated white blood cell count of 16,300/μ L (neutrophils