Higher estrogen levels are not associated with larger hippocampi and better memory performance
Higher estrogen levels are not associated with larger hippocampi and better memory performance
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DOI：
10.1001/archneur.60.2.213
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发表时间：
2003-02-01
影响因子：
--
通讯作者：
Breteler, MMB
中科院分区：
文献类型：
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作者：
den Heijer, T;Geerlings, MI;Breteler, MMB
背景：雌激素可能预防认知能力下降和阿尔茨海默病。动物研究结果表明雌激素对大脑，特别是对海马体有有益作用，海马体是一种与记忆表现和早期阿尔茨海默病相关的结构。
目的：研究老年女性和男性体内较高水平的内源性雌二醇是否与磁共振成像显示的较大海马体体积以及更好的记忆表现相关。
设计与环境：鹿特丹扫描研究中的横断面分析，这是一项在荷兰针对无痴呆的老年受试者进行的基于人群的研究。
参与者：210名女性和202名男性，年龄在60至90岁之间，有血浆总雌二醇水平，其中部分162名女性和149名男性还有生物可利用及游离雌二醇水平。
主要观察指标：磁共振成像显示的海马体体积和记忆表现（延迟回忆）。
结果：总雌二醇水平较高的女性海马体体积较小，记忆表现较差，与最低三分位数相比，最高三分位数在延迟回忆测试中少记 -0.29毫升（95%置信区间，-0.57至 -0.00）和 -0.4个单词（95%置信区间，-1.3至0.5）。在生物可利用及游离雌二醇水平、海马体体积和记忆之间也发现了类似的负相关。在男性中，未观察到雌二醇水平与海马体体积之间存在关联，但发现总雌二醇水平较高与记忆表现较差存在趋势。
结论：我们的数据不支持老年女性和男性体内较高水平的内源性雌二醇与较大海马体体积和更好记忆表现相关这一假设。
Background: Estrogens may prevent cognitive decline and Alzheimer disease. Animal study findings have shown beneficial effects of estrogen on the brain, particularly on the hippocampus, a structure related to memory performance and early Alzheimer disease.Objective: To investigate whether higher levels of endogenous estradiol in older women and men are associated with larger hippocampal volumes on magnetic resonance imaging and better memory performance.Design and Setting: Cross-sectional analysis within the Rotterdam Scan Study, a population-based study in the Netherlands of elderly subjects who do not have dementia.Participants: Two hundred ten women and 202 men, aged 60 to 90 years, with plasma levels of total estradiol and, in part, 162 women and 149 men also with levels of bioavailable and free estradiol.Main Outcome Measure: Hippocampal volumes on magnetic resonance imaging and memory performance (delayed recall).Results: Women with higher total estradiol levels had smaller hippocampal volumes and poorer memory performance -0.29 mL (95% confidence interval, -0.57 to -0.00) and -0.4 (95% confidence interval, -1.3 to 0.5) fewer words in delayed recall testing for the highest tertile compared with the lowest tertile. Similar inverse associations were found among bioavailable and free estradiol levels, hippocampal volumes, and memory. In men, no association was observed between estradiol levels and hippocampal. volume, but a trend was found for higher levels of total estradiol to be associated with poorer memory performance.Conclusion: Our data do not support the hypothesis that higher levels of endogenous estradiol in older women and men are associated with larger hippocampal volumes and better memory performance.