Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma
Pathological grading for predicting metastasis in phaeochromocytoma and paraganglioma
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DOI：
10.1530/erc-13-0494
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发表时间：
2014-06-01
影响因子：
3.9
通讯作者：
Naruse, Mitsuhide
中科院分区：
文献类型：
--
作者：
Kimura, Noriko;Takayanagi, Ryoichi;Naruse, Mitsuhide
嗜铬细胞瘤（PHEO）和副神经节瘤是罕见的产生儿茶酚胺的肿瘤。尽管这些肿瘤中有10-30%发生转移，但尚未建立区分恶性和良性肿瘤的组织病理学标准，因此迫切需要预测转移的可靠组织病理学标记。使用称为肾上腺嗜铬细胞瘤和副神经节瘤分级系统（GAPP）的系统对日本嗜铬细胞瘤研究组（PHEO-J）收集的总共163个肿瘤（包括40个转移性肿瘤）进行了分析。根据GAPP标准对肿瘤进行评分，如下：组织学模式、细胞结构、粉刺型坏死、包膜/血管侵犯、Ki67标记指数和儿茶酚胺类型。所有肿瘤的评分为0至10分，并被分级为三种类型之一：高分化（WD 0-2分）、中分化（MD 3-6分）和低分化（PD 7-10分）。非转移组和转移组的 GAPP 评分分别为 2.08 +/- 0.17 和 5.33 +/- 0.43（平均值 +/- S.E.M.P
Phaeochromocytomas (PHEO) and paragangliomas are rare catecholamine-producing tumours. Although 10-30% of these tumours metastasise histopathological criteria to discriminate malignant from benign tumours have not been established therefore reliable histopathological markers predicting metastasis are urgently required. A total of 163 tumours including 40 metastatic tumours collected by the Phaeochromocytoma Study Group in Japan (PHEO-J) were analysed using a system called grading system for adrenal phaeochromocytoma and paraganglioma (GAPP). The tumours were scored based on GAPP criteria as follows: histological pattern cellularity comedo-type necrosis capsular/vascular invasion Ki67 labelling index and catecholamine type. All tumours were scored from 0 to 10 points and were graded as one of the three types: well-differentiated (WD 0-2 points) moderately differentiated (MD 3-6 points) and poorly differentiated (PD 7-10 points). GAPP scores of the non-metastatic and metastatic groups were 2.08 +/- 0.17 and 5.33 +/- 0.43 (mean +/- S. E. M. P