Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus.
Amerindian ancestry in Argentina is associated with increased risk for systemic lupus erythematosus.
复制标题
阿根廷的美洲印第安人血统与系统性红斑狼疮风险增加有关。
DOI：
10.1038/gene.2008.25
复制
发表时间：
2008
影响因子：
5
通讯作者：
Abder
中科院分区：
文献类型：
--
作者：
Seldin,MF;Qi,L;Scherbarth,HR;Tian,C;Ransom,M;Silva,G;Belmont,JW;Gamron,S;Allievi,A;Palatnik,SA;Saurit,V;Paira,S;Graf,C;Guilleron,C;Catoggio,LJ;Prigione,C;Berbotto,GA;Garcia,MA;Perandones,CE;Truedsson,L;Abder
先前的研究表明，在混合人群中，西非血统与系统性红斑狼疮（SLE）患病率增加有关。在目前的研究中，在阿根廷的一个混合人群中研究了美洲印第安人血统对SLE的影响。阿根廷人口主要是欧洲人，约20%是美洲印第安人，西非人口的贡献很小（< 2%）。结果表明，该人群中的美洲印第安混血与SLE易感性风险的显著增加相关（优势比= 7.94，P= 0.00006）。这种差异不是由于已知的人口因素，包括收集地点、年龄和性别。此外，美洲印第安人血统对肾脏疾病、发病年龄和抗ssa抗体有显著影响。这些研究表明，在未来的研究中，应该考虑具有美洲印第安混血的人群，就像那些具有西非混血的人群一样，以确定易患SLE的其他等位基因变异。
Previous studies have demonstrated that in admixed populations, West African ancestry is associated with an increased prevalence of systemic lupus erythematosus (SLE). In the current study, the effect of Amerindian ancestry in SLE was examined in an admixed population in Argentina. The Argentine population is predominantly European with approximately 20% Amerindian admixture, and a very small (< 2%) contribution from West Africa. The results indicate that Amerindian admixture in this population is associated with a substantial increase in SLE susceptibility risk (Odds Ratio= 7.94, P= 0.00006). This difference was not due to known demographic factors, including site of collection, age and gender. In addition, there were trends towards significance for Amerindian ancestry influencing renal disease, age of onset and anti-SSA antibodies. These studies suggest that populations with Amerindian admixture, like those with West African admixture, should be considered in future studies to identify additional allelic variants that predispose to SLE.