Heritability of ambulatory heart rate variability
Heritability of ambulatory heart rate variability
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DOI：
10.1161/01.cir.0000146334.96820.6e
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发表时间：
2004-11-02
期刊：
影响因子：
37.8
通讯作者：
de Geus, EJC
中科院分区：
文献类型：
--
作者：
Kupper, NHM;Willemsen, G;de Geus, EJC
背景-心率变异性（HRV）降低是心脏病和心脏病死亡率的一个预后因素.了解HRV个体差异的来源可能会增加其诊断用途，并为预防性治疗提供新的角度。到目前为止，遗传和环境因素对HRV方差的贡献还没有被调查，在一个naturalistic setting.Methods和结果-在772健康的双胞胎和独生子女的兄弟姐妹，动态心电图记录在24小时内长时间的动态监测。使用两种时域测量HRV：5分钟段内所有正常至正常间期的标准差（SDNN指数）和相邻正常RR间期之间连续差异的均方根（RMSSD）。一天中4个时段的多变量遗传分析（上午，下午，晚上，夜间）对平均动态SDNN指数的遗传贡献产生了显著估计（范围从35%到47%）和平均动态RMSSD（由40%至48%不等）。动态心率变异性测量是高度可遗传的特征，可用于支持遗传关联和连锁研究，以寻找影响心血管疾病的遗传变异风险
Background - Reduced heart rate variability (HRV) is a prognostic factor for cardiac disease and cardiac mortality. Understanding the sources of individual differences in HRV may increase its diagnostic use and provide new angles for preventive therapy. To date, the contribution of genetic and environmental factors to the variance in HRV has not been investigated during prolonged periods of ambulatory monitoring in a naturalistic setting.Methods and Results - In 772 healthy twins and singleton siblings, ambulatory ECG was recorded during 24 hours. Two time domain measures of HRV were used: the standard deviations of all normal-to-normal intervals across 5-minute segments (SDNN index) and the root mean square of successive differences between adjacent normal RR intervals (RMSSD). Multivariate genetic analyses across 4 periods of day ( morning, afternoon, evening, night) yielded significant estimates for genetic contribution to the mean ambulatory SDNN index ( ranging from 35% to 47%) and the mean ambulatory RMSSD ( ranging from 40% to 48%).Conclusions - Ambulatory HRV measures are highly heritable traits that can be used to support genetic association and linkage studies in their search for genetic variation influencing cardiovascular disease risk.