Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet
Dairy calcium intake modifies responsiveness of fat metabolism and blood lipids to a high-fat diet
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DOI：
10.1017/s0007114510005581
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发表时间：
2011-06-01
影响因子：
3.6
通讯作者：
Astrup, Arne
中科院分区：
文献类型：
--
作者：
Lorenzen, Janne K.;Astrup, Arne
干预研究表明，饱和脂肪会增加总胆固醇和低密度脂蛋白胆固醇浓度，因此建议限制高脂肪乳制品的摄入。然而，观察性研究发现，乳制品的摄入量与CVD的发病率呈反比关系。我们的目的是研究是否钙含量的乳制品的影响，乳脂肪对血脂谱的效果。该研究采用随机交叉设计。受试者（n 9）被随机分配到四个等能10天饮食序列之一：低钙和低脂（LC/LF：约700 mg Ca/d，能量（脂肪）的25%;高Ca和LF（HC/LF：约2800 mg Ca/d，能量脂肪的25%）; LC和高脂肪（LC/HF：约700 mg Ca/d，49 E %脂肪）;或HC和HF（约2800 mg Ca/d，49 E%脂肪）。在每个饮食期之前和之后测量血液变量，并在每个饮食期结束时收集粪便和尿液。使用双因素方差分析来检查Ca和脂肪摄入的影响。不依赖于钙的摄入，HF饮食增加了总的浓度（9%; P
Intervention studies have demonstrated that saturated fat increases total and LDL-cholesterol concentrations, and it is therefore recommended that the intake of high-fat dairy products be limited. However, observational studies have found an inverse relationship between the intake of dairy products and incidence of CVD. We aimed to study whether the Ca content of dairy products influences the effect of dairy fat on the lipid profile. The study had a randomised cross-over design. Subjects (n 9) were randomised to one of the sequence of four isoenergetic 10 d diets: low Ca and low fat (LC/LF: approximately 700mg Ca/d, 25% of energy (fat); high Ca and LF (HC/LF: approximately 2800 mg Ca/d, 25% of energy fat); LC and high fat (LC/HF: approximately 700 mg Ca/d, 49E% fat); or HC and HF (approximately 2800mg Ca/d, 49 E% fat). Blood variables were measured before and after each diet period, and faeces and urine were collected at the end of each diet period. A two-way ANOVA was used to examine the effect of Ca and fat intake. Independent of Ca intake, the HF diet increased the concentrations of total (9 %; P