Enantioselective assembly of substituted dihydropyrones via organocatalytic reaction in water media.
Enantioselective assembly of substituted dihydropyrones via organocatalytic reaction in water media.
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DOI：
10.1021/ol800835m
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发表时间：
2008-05
期刊：
影响因子：
5.2
通讯作者：
Jing Wang;Fanglei Yu;Xiaojing Zhang;D. Ma
中科院分区：
文献类型：
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作者：
Jing Wang;Fanglei Yu;Xiaojing Zhang;D. Ma
二芳基脯氨醇醚/HOAc催化的醛和α-酮-α，β-不饱和酯的Michael加成和环化级联反应在水中顺利进行，得到环状半缩醛，其被氧化得到高度官能化的3，4，5，6-四取代二氢吡喃酮，具有优异的对映选择性。
The diarylprolinol ether/HOAc-catalyzed cascade Michael addition and cyclization of aldehydes and alpha-keto-alpha,beta-unsaturated esters proceeds smoothly in water to afford cyclic hemiacetals, which are oxidized to furnish highly functionalized 3,4,5,6-tetrasubstituted dihydropyrones with excellent enantioselectivities.