Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia
Comparison of the continuous performance test with and without working memory demands in healthy controls and patients with schizophrenia
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DOI：
10.1016/s0920-9964(00)00060-8
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发表时间：
2001-03-30
影响因子：
4.5
通讯作者：
Gur, RE
中科院分区：
文献类型：
--
作者：
Kurtz, MM;Ragland, JD;Gur, RE
Penn 连续性能测试 (PCPT) 是一种为功能性神经影像研究而开发的持续视觉注意力测量方法，与 Gordon Diagnostic Systems 开发的标准 CPT（GDS；警惕子测试）进行了比较。 PCPT 和 GDS CPT 采用标准神经心理学电池对 68 名健康成年人进行，以评估可靠性和构建有效性。该测试具有足够的内部一致性，并且通过 PCPT 和 GDS CPT 效率测量之间的显着相关性建立了收敛效度。除了 GDS CPT 的效率测量与听觉持续注意力测量之间存在显着相关性之外，CPT 的两个版本都与电池组中的其他测量显着相关。因子分析显示，PCPT 与 GDS CPT 一起加载，在 39 名精神分裂症患者和 39 名匹配的健康对照者中，两项 CPT 任务的损害相当明显。这两个版本都与症状测量值显着相关。这些结果支持了之前的结论，即精神分裂症患者的持续视觉注意力是核心信息处理缺陷，与症状没有直接关系。 (C) 2001 Elsevier Science B.V. 保留所有权利。
The Penn Continuous Performance Test (PCPT), a measure of sustained visual attention developed for use in functional neuroimaging studies, was compared with a standard CPT developed by Gordon Diagnostic Systems (GDS; Vigilance subtest). The PCPT and the GDS CPT were administered with a standard neuropsychological battery to 68 healthy adults to assess reliability and construct validity. The test had adequate internal consistency, and convergent validity was established through significant correlations between measures of efficiency on the PCPT and the GDS CPT. With the exception of a significant correlation between efficiency measures on the GDS CPT and a measure of auditory sustained attention, neither version of the CPT correlated significantly with other measures in the battery. Factor analysis showed that the PCPT loaded with the GDS CPT, In 39 patients with schizophrenia and 39 matched, healthy controls, equivalent impairment was evident on the two CPT tasks. Neither version correlated significantly with symptom measurements. These results support previous conclusions that sustained visual attention in schizophrenia is a core information processing deficit, not directly related to symptomatology. (C) 2001 Elsevier Science B.V. All rights reserved.