Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA
Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA
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DOI：
10.1136/ard.60.3.223
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发表时间：
2001-03-01
影响因子：
27.4
通讯作者：
Lynch, MP
中科院分区：
文献类型：
--
作者：
Hutchinson, D;Shepstone, L;Lynch, MP
目的是研究患有或没有类风湿关节炎（RA）患者累积暴露于香烟吸烟的潜在关系与疾病的积极家族病史。方法-239基于RA的门诊患者与年龄，性别，性别相匹配的239例对照组进行了比较。和社会阶层。记录了详细的吸烟史，并表示为吸烟年的吸烟史。有条件的逻辑回归用于计算RA和烟熏年之间的关联。 RA患者还接受了有关疾病家族史的访谈，并记录为IFA阳性一级或二级亲戚RA。 RA患者研究时的吸烟史直接将其与各自对照的患者进行了比较。在疾病发作时，还可以追溯地比较患有有或没有该疾病家族史的RA患者。当前的吸烟。分析 - 烟熏年与RA之间的增加相关性。大烟吸烟与RA之间存在着惊人的联系。吸烟41 - 50年的历史与RA相关（赔率（OR）13.54，95％置信区间（95％CI）2.89至63.38; P
Objectives-To investigate the potential relation between cumulative exposure to cigarette smoking in patients with or without rheumatoid arthritis (RA) and a positive family history of the disease.Methods-239 outpatient based patients with RA were compared with 239 controls matched for age, sex, and social class. A detailed smoking history was recorded and expressed as pack years smoked. Conditional logistic regression was used to calculate the association between RA and pack years smoked. The patients with RA were also interviewed about a family history of disease and recorded as positive ifa first or second degree relative had RA. The smoking history at the time of the study of the patients with RA with or without a family history of the disease was compared directly with that of their respective controls. Patients with RA with or without a family history of the disease were also compared retrospectively for current smoking at the time of disease onset.Results-An increasing association between increased pack years smoked and RA was found. There was a striking association between heavy cigarette smoking and RA. A history for 41-50 pack years smoked was associated with RA (odds ratio (OR) 13.54, 95% confidence interval (95% CI) 2.89 to 63.38; p