Prescription opioid abuse in patients presenting for methadone maintenance treatment
Prescription opioid abuse in patients presenting for methadone maintenance treatment
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DOI：
10.1016/j.drugalcdep.2003.10.012
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发表时间：
2004-02-07
影响因子：
4.2
通讯作者：
Busto, U
中科院分区：
文献类型：
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作者：
Brands, B;Blake, J;Busto, U
为了描述美沙酮维持治疗（MMT）项目中处方阿片类药物依赖患者的特征，对新入院患者（1997-1999,n = 178，平均年龄= 34.5+/-0.7岁，65%男性）进行了详细的回顾性图表回顾。入院时，大多数患者（83%）一直在使用处方阿片类药物（海洛因）。确定了四组：24%仅使用处方阿片类药物；24%的人最初使用处方阿片类药物，后来使用海洛因；35%先使用海洛因，后使用处方阿片类药物；17%仅使用海洛因（该组明显年轻化：平均年龄26+/-1岁，P = 0.0001）。受试者报告经常使用高于治疗剂量的处方阿片类药物。例如，在“仅处方阿片类药物”组中，报告的可待因或含羟考酮片剂的平均（+/-S.E）日用量分别为23（+/-6）片和21（+/-3）片。在社会稳定性方面，各组之间没有显著差异。那些仅依赖处方阿片类药物的人不太可能使用非法非阿片类药物或与注射药物使用有关。那些只使用处方阿片类药物或最初使用处方阿片类药物的人更有可能出现持续的疼痛问题，并参与精神治疗。需要进一步研究以更好地阐明疼痛、心理健康和成瘾之间的复杂关系，以便制定处方阿片类药物依赖的最佳预防和治疗策略。2003爱思唯尔爱尔兰有限公司版权所有。
To characterize prescription opioid dependent patients in a methadone maintenance treatment (MMT) program, a detailed retrospective chart review of new admissions (1997-1999, n = 178, mean age = 34.5+/-0.7 years, 65% male) was conducted. At admission most patients (83%) had been using prescription opioids (heroin). Four groups were identified: 24% had used prescription opioids only; 24% used prescription opioids initially and heroin later; 35% used heroin first and prescription opioids subsequently; and 17% had used heroin only (this group was significantly younger: mean age 26+/-1 years, P = 0.0001). Subjects reported regular use of prescription opioids at higher than therapeutic dosages. For example, in the 'prescription opioid only' group the reported mean (+/-S.E.) number of codeine or oxycodone-containing tablets consumed daily was 23(+/-6) tablets and 21(+/-3) tablets, respectively. There were no significant differences found amongst the groups in measures of social stability. Those dependent on prescription opioids alone were less likely to use illicit non-opioid drugs or to be associated with injection drug use. Those that used prescription opioids only or initially were more likely to have ongoing pain problems and to be involved in psychiatric treatment. Further research is required to better elucidate the complex relationships between pain, mental health and addiction in order to develop optimal prevention and treatment strategies for prescription opioid dependence. (C) 2003 Elsevier Ireland Ltd. All rights reserved.