IMMUNOGENIC STRUCTURE OF THE INFLUENZA-VIRUS HEMAGGLUTININ
IMMUNOGENIC STRUCTURE OF THE INFLUENZA-VIRUS HEMAGGLUTININ
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DOI：
10.1016/0092-8674(82)90202-1
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发表时间：
1982-01-01
期刊：
影响因子：
64.5
通讯作者：
LERNER, RA
中科院分区：
文献类型：
--
作者：
GREEN, N;ALEXANDER, H;LERNER, RA
化学合成了20个多肽，相当于流感病毒HA1分子的75%。这些多肽中的大多数(18)的抗体能够与血凝素分子反应。这18个肽并不局限于已知的血凝素分子的抗原决定簇，而是分散在其三维结构中。抗完整血凝素的抗体与20个多肽中的任何一个都不反应。因此，一个完整的蛋白质分子的免疫原性显然不是其片段的免疫原性的总和。
Twenty peptides corresponding to 75% of the HA1 molecule of the influenza virus were chemically synthesized. Antibodies to the majority (18) of these peptides were capable of reacting with the hemagglutinin molecule. These 18 peptides are not confined to the known antigenic determinants of the hemagglutinin molecule but are scattered throughout its 3-dimensional structure. Antibody raised to intact hemagglutinin did not react with any of the 20 peptides. Thus, the immunogenicity of an intact protein molecule apparently is not the sum of the immunogenicity of its pieces.