At the heart of accelerated old matter.
At the heart of accelerated old matter.
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处于加速旧物质的核心。
DOI：
10.1113/jp273656
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Botting KJ
中科院分区：
文献类型：
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作者：
Botting KJ
现在非常清楚的是，在设定心脏病风险方面，早期生命中的遗传环境相互作用可能与基因-成人生活方式相互作用一样重要，如果不是更重要的话。同样，宫内心脏形态的改变不仅可能引发先天性心脏病，还会显著影响成年后的心功能。一些研究已经报道，早期生命中的次优条件会对成年后代心脏的形态和功能表型产生不利影响。这些研究包括怀孕期间母亲营养改变的研究(Langley-Evans，2009；Loche&Ozanne，2016)，过量糖皮质激素暴露(Nyirenda&Seckl，1998；Singh等人)。胎儿氧合受损(Patterson&Zhang，2010；Giussani&Davidge，2013)。重要的是，这些研究中的许多报告表明，在成年后代中，明显的心脏和内皮功能障碍的早期生活规划并不总是伴随着高血压。因此，这些研究强调，在没有更深入的心血管功能分析的情况下，常规测量动脉血压对因怀孕期间不利条件而编程的后代心血管病理的临床诊断几乎没有帮助。
It is now abundantly clear that the geneenvironment interaction in early life may be just as important as the gene–adult lifestyle interaction in setting a risk of heart disease, if not more so. Likewise, alterations in cardiac morphology in utero may not only trigger congenital heart disease but also significantly influence cardiac function in adulthood. Several studies have reported that suboptimal conditions during early life can adversely affect the morphology and functional phenotype of the heart of the adult offspring. These include studies during pregnancy of altered maternal nutrition (Langley-Evans, 2009; Loche & Ozanne, 2016), excess glucocorticoid exposure (Nyirenda & Seckl, 1998; Singh et al. 2012) and impaired fetal oxygenation (Patterson & Zhang, 2010; Giussani & Davidge, 2013). Importantly, many of these studies have reported that the early life programming of pronounced cardiac and endothelial dysfunction does not always accompany hypertension in the adult offspring. Therefore, the studies highlight that routine measurement of arterial blood pressure without deeper functional cardiovascular analysis adds little to the clinical diagnosis of cardiovascular pathology in the offspring, programmed by adverse conditions during pregnancy in humans.