Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE
Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE
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DOI：
10.1093/humrep/dem053
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发表时间：
2007-06-01
影响因子：
6.1
通讯作者：
Nygren, K. G.
中科院分区：
文献类型：
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作者：
Andersen, A. Nyboe;Goossens, V.;Nygren, K. G.
背景：欧洲在2003年启动的辅助生殖技术(ARTS)治疗的结果在这份第七次报告中提出。方法：数据主要来自已有的国家登记。来自28个国家的725个诊所报告了365个103个治疗周期：试管受精132 932个，ICSI 162 149个，冷冻胚胎置换(FER)60 412个，卵母细胞捐献(OD)7548个，PGD/PGS 1956个和IVM 109个。总体而言，这意味着自2002年以来增长了13%。19个国家第三次报告了欧洲宫内人工授精(IUIS)数据的结果。共99577个周期(IUI-H，82834个；IUI-D，16743个)。结果：在所有诊所都向登记处报告的15个国家中，在2.787亿人口中共进行了284765个周期，相当于每百万居民1022个周期。IVF每次抽吸和移植的临床妊娠率分别为26.1%和29.6%。ICSI的相应发生率分别为26.5%和28.7%。IUI-H治疗后，40岁以下妇女的临床妊娠率为12.2%，40岁以下妇女的临床妊娠率为8.8%。IVF和ICSI后，移植1、2、3和4个以上胚胎的比例分别为15.7%、55.9%、24.9%和3.5%。与2002年相比，移植的胚胎较少，但各国之间仍存在巨大差异。IVF和ICSI的单胎、双胞胎和三胞胎分娩比例分别为76.7%、22.0%和1.1%。这使得多重递送的总比率为23.1%，而2002年为24.5%。IVF和ICSI后的三胞胎接生率在不同国家之间从0.0%到4.4%不等。40岁以下妇女行IUI-H后，11.4%为双胞胎妊娠，2.2%为三胞胎妊娠。
BACKGROUND: European results of assisted reproductive techniques (ARTs) from treatments initiated during 2003 are presented in this seventh report. METHODS: Data were mainly collected from already existing national registers. From 28 countries, 725 clinics reported 365 103 treatment cycles with: IVF 132 932, ICSI 162 149, frozen embryo replacement (FER) 60 412, oocyte donation (OD) 7548, PGD/PGS 1956 and IVM 109. Overall, this represents a 13% increase since 2002. For the third time, results on European data on intrauterine inseminations (IUIs) were reported from 19 countries. A total of 99 577 cycles (IUI-H, 82 834; IUI-D, 16 743) were included. RESULTS: In those 15 countries where all clinics reported to the register, a total of 284 765 cycles were performed in a population of 278.7 million, corresponding to 1022 cycles per million inhabitants. For IVF, the clinical pregnancy rates per aspiration and per transfer were 26.1 and 29.6%, respectively. For ICSI, the corresponding rates were 26.5 and 28.7%. After IUI-H, the clinical pregnancy rate was 12.2% in women below 40 years and 8.8% in women >= 40 years. After IVF and ICSI, the distribution of transfer of one, two, three and four or more embryos was 15.7, 55.9, 24.9 and 3.5%, respectively. Compared to the year 2002, fewer embryos were transferred, but huge differences still exist between countries. The distribution of singleton, twin and triplet deliveries for IVF and ICSI combined was 76.7, 22.0 and 1.1%, respectively. This gives a total multiple delivery rate of 23.1% compared with 24.5% in 2002. The range of triplet deliveries after IVF and ICSI varied from 0.0 to 4.4% between countries. After IUI-H in women below 40 years of age, 11.4% were twin and 2.2% triplet gestations.