Bioinformatic tools for microRNA dissection.
Bioinformatic tools for microRNA dissection.
复制标题
MicroRNA解剖的生物信息学工具。
DOI：
10.1093/nar/gkv1221
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发表时间：
2016-01-08
影响因子：
14.9
通讯作者：
Procopio AD
中科院分区：
文献类型：
--
作者：
Akhtar MM;Micolucci L;Islam MS;Olivieri F;Procopio AD
最近，microRNAs（miRNAs）已成为基因调控网络的重要组成部分。miRNAs是内源性单链非编码RNA（约22nt长），其在转录后水平调节基因表达。通过与mRNA配对，miRNA可以通过抑制翻译或刺激mRNA降解来下调基因表达。在某些情况下，它们还可以上调靶基因的表达。miRNAs影响从发育到癌变的多种细胞途径。miRNAs参与多种人类疾病，特别是癌症，使其成为潜在的诊断和预后生物标志物。最近的技术进步，特别是高通量测序，导致了miRNA相关数据的生成呈指数级增长。已经设计了许多生物信息学工具和数据库来管理这些不断增长的数据。我们分析了129种用于miRNA研究不同领域的miRNA工具，以帮助研究人员选择最适合他们需求的工具。
Recently, microRNAs (miRNAs) have emerged as important elements of gene regulatory networks. MiRNAs are endogenous single-stranded non-coding RNAs (∼22-nt long) that regulate gene expression at the post-transcriptional level. Through pairing with mRNA, miRNAs can down-regulate gene expression by inhibiting translation or stimulating mRNA degradation. In some cases they can also up-regulate the expression of a target gene. MiRNAs influence a variety of cellular pathways that range from development to carcinogenesis. The involvement of miRNAs in several human diseases, particularly cancer, makes them potential diagnostic and prognostic biomarkers. Recent technological advances, especially high-throughput sequencing, have led to an exponential growth in the generation of miRNA-related data. A number of bioinformatic tools and databases have been devised to manage this growing body of data. We analyze 129 miRNA tools that are being used in diverse areas of miRNA research, to assist investigators in choosing the most appropriate tools for their needs.