Cinnamaidehyde - A potential antidiabetic agent
Cinnamaidehyde - A potential antidiabetic agent
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DOI：
10.1016/j.phymed.2006.11.005
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发表时间：
2007-01-01
期刊：
影响因子：
7.9
通讯作者：
Ignacimuthu, S.
中科院分区：
文献类型：
--
作者：
Babu, P. Subash;Prabuseenivasan, S.;Ignacimuthu, S.
肉桂是印度传统医学体系中广泛使用的治疗糖尿病的药物。本研究基于生物测定导向分级分离和鉴定可能的抗糖尿病化合物；鉴定出的化合物可降低血糖水平。活性物质经重复柱层析纯化，并根据化学和物理化学证据确定其结构。肉桂醛的LD50为1850+/-37 mg/kgbw。以链脲佐菌素(STZ)(60 mg/kgbw)诱导雄性Wistar糖尿病大鼠，给予不同剂量(5、10、20 mg/kgbw)的肉桂醛，连续45d。结果发现，与对照组相比，血糖浓度显著降低(p<；0.05)，且呈剂量依赖关系(63.29%)。此外，口服肉桂醛(20 mg/kg bw)可显著降低糖化血红蛋白(HbA(1c))、血清总胆固醇、甘油三酯水平，同时显著升高血浆胰岛素、肝糖原和高密度脂蛋白-胆固醇水平。肉桂醛还使改变的血浆酶(天冬氨酸氨基转移酶、丙氨酸氨基转移酶、乳酸脱氢酶、碱性磷酸酶和酸性磷酸酶)恢复到接近正常的水平。给予参比药物格列本脲(0.6 mg/kg bw)也能显著降低STZ诱导的糖尿病大鼠的血糖浓度(p<；0.05)。本实验结果表明，肉桂醛对链脲佐菌素诱导的糖尿病大鼠具有降血糖、降血脂作用。(C)2006年爱思唯尔股份有限公司。版权所有。
Cinnamonum zeylanicum (cinnamon) is widely used in traditional system of medicine to treat diabetes in India. The present study was carried out to isolate and identify the putative antidiabetic compounds based on bioassay-guided fractionation; the compound identified decreased the plasma glucose levels. The active compound was purified by repeat column and structure of cinnamaldehyde was determined on the basis of chemical and physiochemical evidence. The LD50 value of cinnamaldehyde was determined as 1850 +/- 37mg/kg bw. Cinnamaldehyde was administered at different doses (5, 10 and 20mg/kg bw) for 45 days to streptozotocin (STZ) (60mg/kg bw)-induced male diabetic wistar rats. It was found that plasma glucose concentration was significantly (p < 0.05) decreased in a dose-dependent manner (63.29%) compared to the control. In addition, oral administration of cinnamaldehyde (20mg/kg bw) significantly decreased glycosylated hemoglobin (HbA(1c)), serum total cholesterol, triglyceride levels and at the same time markedly increased plasma insulin, hepatic glycogen and high-density lipoprotein-cholesterol levels. Also cinnamaldehyde restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal. Administration of glibenclamide, a reference drug (0.6mg/kg bw) also produced a significant (p < 0.05) reduction in blood glucose concentration in STZ-induced diabetic rats. The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats. (c) 2006 Elsevier GmbH. All rights reserved.