Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome
Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome
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DOI：
10.1016/j.cmet.2019.11.004
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发表时间：
2020-01-07
期刊：
影响因子：
29
通讯作者：
Taub, Pam R.
中科院分区：
文献类型：
--
作者：
Wilkinson, Michael J.;Manoogian, Emily N. C.;Taub, Pam R.
在动物模型中，限时喂养（TRF）可以预防和逆转代谢性疾病。人类试点研究中的限时进食（TRE）降低了健康个体患代谢性疾病的风险。然而，诊断出代谢综合征的患者经常接受药物治疗，并且从未在动物模型或人体中测试过TRE是否可以与药物治疗产生协同作用。在一项单臂、配对样本试验中，19名患有代谢综合征且基线平均每日进食时间窗>= 14 h的受试者（其中大多数正在接受他汀类药物和/或抗高血压治疗）接受10 h TRE（所有饮食摄入均在一致的自选10 h窗口内），持续12周。我们发现，TRE干预改善了接受标准医疗护理（包括高比例使用他汀类药物和抗高血压药物）的代谢综合征患者的心脏代谢健康。TRE是一种潜在的强大的生活方式干预，可以添加到标准的医疗实践中来治疗代谢综合征。
In animal models, time-restricted feeding (TRF) can prevent and reverse aspects of metabolic diseases. Time-restricted eating (TRE) in human pilot studies reduces the risks of metabolic diseases in otherwise healthy individuals. However, patients with diagnosed metabolic syndrome often undergo pharmacotherapy, and it has never been tested whether TRE can act synergistically with pharmacotherapy in animal models or humans. In a single-arm, paired-sample trial, 19 participants with metabolic syndrome and a baseline mean daily eating window of >= 14 h, the majority of whom were on a statin and/or antihypertensive therapy, underwent 10 h of TRE (all dietary intake within a consistent self-selected 10 h window) for 12 weeks. We found this TRE intervention improves cardiometabolic health for patients with metabolic syndrome receiving standard medical care including high rates of statin and anti-hypertensive use. TRE is a potentially powerful lifestyle intervention that can be added to standard medical practice to treat metabolic syndrome.