Alkaloids from Traditional Chinese Medicine against hepatocellular carcinoma
Alkaloids from Traditional Chinese Medicine against hepatocellular carcinoma
复制标题
中药生物碱抗肝细胞癌
DOI：
10.1016/j.biopha.2019.109543
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发表时间：
2019-12-01
影响因子：
7.5
通讯作者：
Yu, Haiyang
中科院分区：
文献类型：
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作者：
Liu, Caiyan;Yang, Shenshen;Yu, Haiyang
肝细胞癌（Hepatocellular carcinoma，HCC）已成为世纪威胁人类健康的主要疾病之一。目前治疗肝癌的方法有很多，但每种方法都有自己的优点和缺点。在治疗肝癌的各种方法中，天然药物治疗以其高效、有效、副作用小等优势，取得了可喜的成果。生物碱作为一类天然中药成分，具有显著的抗肝癌作用，其作用机制包括抑制细胞增殖、转移和血管生成，改变细胞形态，促进细胞凋亡和自噬，触发细胞周期阻滞，调节多种肿瘤相关基因和通路等。生物碱抑制肝癌的发展和进展。本研究按照结构分类，将生物碱主要分为哌啶类生物碱、异喹啉类生物碱、吲哚类生物碱、萜类生物碱、甾体类生物碱和其他生物碱，系统地阐述了各大类中具有代表性的生物碱抗肝癌的机制。除单独使用外，与其他化疗药物及某些特殊制备方法的协同作用也已得到证实。本文综述了几种常见生物碱在肝癌预防和治疗中的潜在作用，通过修订临床前研究，强调生物碱作为肝癌治疗的治疗选择时的潜在应用，并将其整合到临床实践中。
Hepatocellular carcinoma (HCC) has become one of the major diseases that are threatening human health in the 21st century. Currently there are many approaches to treat liver cancer, but each has its own advantages and disadvantages. Among various methods of treating liver cancer, natural medicine treatment has achieved promising results because of their superiorities of high efficiency and availability, as well as low side effects. Alkaloids, as a class of natural ingredients derived from traditional Chinese medicines, have previously been shown to exert prominent anti-hepatocarcinogenic effects, through various mechanisms including inhibition of proliferation, metastasis and angiogenesis, changing cell morphology, promoting apoptosis and autophagy, triggering cell cycle arrest, regulating various cancer-related genes as well as pathways and so on. As a consequence, alkaloids suppress the development and progression of liver cancer. In this study, the mechanisms of representative alkaloids against hepatocarcinoma in each class are described systematically according to the structure classification, which mainly divides alkaloids into piperidine alkaloids, isoquinoline alkaloids, indole alkaloids, terpenoids alkaloids, steroidal alkaloids and other alkaloids. Besides using them alone, synergistic effects created together with other chemotherapy drugs and some special preparation methods also have been demonstrated. In this review, we have summarized the potential roles of several common alkaloids in the prevention and treatment of HCC, by revising the preclinical studies, highlighting the potential applications of alkaloids when they function as a therapeutic choice for HCC treatment, and integrating them into clinical practices.