Susceptibility of Anaerobic Bacteria to Ten Antimicrobial Agents
Susceptibility of Anaerobic Bacteria to Ten Antimicrobial Agents
复制标题
厌氧菌对十种抗菌药物的敏感性
DOI：
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发表时间：
1978
影响因子：
4.9
通讯作者：
Sheila A. Chatterton
中科院分区：
文献类型：
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作者：
P. Appelbaum;Sheila A. Chatterton
采用琼脂稀释法对临床分离的265株厌氧菌进行了10种抗菌药物的药敏试验。浓度为16 μg/ml的青霉素G对大多数微生物都有活性，但重要的例外是12%的产黑素拟杆菌和24%的B。fragilis菌株。菌株对氨苄青霉素的敏感性与青霉素G相似。羧苄青霉素在≤128 μg/ml时，除少数菌株外，对所有菌株均有抑制作用。头孢孟多的活性低于青霉素类; 82%的B。产黑色素的占B的32%。≤16 μg/ml时，对脆壁梭杆菌的抑制率为75%。四环素耐药的趋势是在许多细菌群体，特别是拟杆菌，梭杆菌和梭菌。所有微生物均对氯霉素和克林霉素敏感，浓度分别为≤16 μg/ml和≤4 μg/ml。红霉素对所有试验菌株的活性均低于克林霉素。甲硝唑和替硝唑对大多数厌氧菌有活性，但各组中均出现少数菌株耐药。B的抗性增加。产黑素杆菌菌株对青霉素的耐受性，以及出现对>16 μg/ml咪唑具有抗性的厌氧菌可能具有治疗意义。
The susceptibility pattern of 265 anaerobic bacteria from clinical isolates to 10 antimicrobial agents was investigated by the agar dilution technique. Penicillin G, in a concentration of 16 μg/ml, was active against most organisms, important exceptions being 12% of Bacteroides melaninogenicus and 24% of B. fragilis strains. The susceptibility of strains to ampicillin was similar to their susceptibility to penicillin G. Carbenicillin, at ≤128 μg/ml, inhibited all but a few strains. Cefamandole was less active than the penicillins; 82% of B. melaninogenicus, 32% of B. fragilis, and 75% of Fusobacterium strains were inhibited by ≤16 μg/ml. A trend towards tetracycline resistance was seen in many bacterial groups, especially Bacteroides, Fusobacterium, and Clostridium. All organisms were susceptible to chloramphenicol and clindamycin in concentrations of ≤16 μg/ml and ≤4 μg/ml, respectively. Erythromycin was less active than clindamycin against all strains tested. Metronidazole and tinidazole were active against most anaerobes, but resistance of a few strains in each group was encountered. The increased resistance of B. melaninogenicus strains to penicillin, and emergence of anaerobes resistant to >16 μg of imidazole per ml may have therapeutic implications.