The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup.
The epidemiology of published norovirus outbreaks: a review of risk factors associated with attack rate and genogroup.
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DOI：
10.1017/s0950268812000234
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发表时间：
2012-07
影响因子：
4.2
通讯作者：
Leon, J. S.
中科院分区：
文献类型：
--
作者：
Matthews, J. E.;Dickey, B. W.;Miller, R. D.;Felzer, J. R.;Dawson, B. P.;Lee, A. S.;Rocks, J. J.;Kiel, J.;Montes, J. S.;Moe, C. L.;Eisenberg, J. N. S.;Leon, J. S.
本研究的目的是通过传播途径和环境检查全球诺如病毒(NOV)暴发的流行趋势，并描述这些特征、病毒攻击率和暴发中基因组I(GI)或基因组II(GII)毒株的出现之间的关系。我们分析了902个RT-PCR确认的人类新发疫情的数据，这些数据提取自对1993年至2011年发表的文章的系统审查，并以“诺沃克病毒”和“暴发”为索引。多元回归分析表明，食品服务和冬季暴发与较高的发病率显著相关。食源性和水源性暴发与多种毒株(Gi+Gii)有关。水源性疫情与GI菌株显著相关，而与医疗保健相关的和冬季疫情与GII菌株相关。这些结果确定了11月疫情检测、预防和控制的重要趋势。
The purpose of this study was to examine global epidemiological trends in human norovirus (NoV) outbreaks by transmission route and setting, and describe relationships between these characteristics, viral attack rates, and the occurrence of genogroup I (GI) or genogroup II (GII) strains in outbreaks. We analysed data from 902 RT-PCR-confirmed, human NoV outbreaks extracted from a systematic review of articles published from 1993 to 2011 and indexed under the terms “norovirus” and “outbreak.” Multivariate regression analyses demonstrated that foodservice and winter outbreaks were significantly associated with higher attack rates. Food- and waterborne outbreaks were associated with multiple strains (GI+GII). Waterborne outbreaks were significantly associated with GI strains, while healthcare-related and winter outbreaks were associated with GII strains. These results identify important trends for epidemic NoV detection, prevention, and control.