Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment
Relative changes in luminal and stromal areas of choroid determined by binarization of EDI-OCT images in eyes with Vogt-Koyanagi-Harada disease after treatment
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DOI：
10.1007/s00417-016-3283-4
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发表时间：
2016-03-01
影响因子：
2.7
通讯作者：
Sakamoto, Taiji
中科院分区：
文献类型：
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作者：
Kawano, Hiroki;Sonoda, Shozo;Sakamoto, Taiji
本研究的目的是通过光学相干断层扫描（OCT）确定Vogt-Koyanagi-Harada病眼脉络膜腔和基质区域的变化。在基线、开始类固醇治疗后1周和1个月通过增强深度成像（EDI-OCT）记录脉络膜图像。将EDI-OCT图像转换为二值化图像，分别测量管腔面积和基质面积，共16例（32只眼），10例（16只眼）有合适的图像可用于二值化分析。管腔面积与脉络膜面积的比值在基线时为0.60 +/- 0.03，在1周时为0.67 +/- 0.04，在1个月时为0.66 +/- 0.04。1周时较基线有显著性增加（P < 0.01），但1周至1个月时无显著性增加。虽然基质和腔面积都减少了，但在1周时基质面积的减少百分比（56.5 +/-7.2%）显著大于腔面积的减少百分比（42.5 +/-12.6%）（P < 0.01）。在开始类固醇治疗后1周，在Vogt-Koyanagi-Harada病的眼中检测到脉络膜面积的显著减少。基质区的减少比管腔区更明显。
The aim of this study was to determine the changes in the luminal and stromal areas of the choroid in eyes with Vogt-Koyanagi-Harada disease by optical coherence tomography (OCT).A retrospective observational study. Choroidal images were recorded by enhanced depth imaging (EDI-OCT) at the baseline, and at 1 week and 1 month after initiating steroid therapy. The EDI-OCT images were converted to binarized images, and the luminal areas and the stromal areas were measured separately.Thirty-two eyes of 16 patients were enrolled, and 16 eyes of 10 patients had suitable images for the binarization analyses. The ratio of the luminal areas to the choroidal areas was 0.60 +/- 0.03 at the baseline, 0.67 +/- 0.04 at 1 week, and 0.66 +/- 0.04 at 1 month. There was a significant increase from the baseline at 1 week (P < 0.01) but not from 1 week to 1 month. Although both the stromal and luminal areas were reduced, the percent reduction of the stromal areas (56.5 +/- 7.2 %) was significantly greater than that of the luminal areas (42.5 +/- 12.6 %) at 1 week (P < 0.01).A significant decrease of the choroidal area was detected in eyes with Vogt-Koyanagi-Harada disease at 1 week after beginning steroid therapy. The decrease was more evident in the stromal area than in the luminal area.