IntOGen-mutations identifies cancer drivers across tumor types.
IntOGen-mutations identifies cancer drivers across tumor types.
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DOI：
10.1038/nmeth.2642
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发表时间：
2013-11
期刊：
影响因子：
48
通讯作者：
Lopez-Bigas N
中科院分区：
文献类型：
--
作者：
Gonzalez-Perez A;Perez-Llamas C;Deu-Pons J;Tamborero D;Schroeder MP;Jene-Sanz A;Santos A;Lopez-Bigas N
IntOGen-mutations是癌症研究人员发现基因和途径中驱动突变的发现工具。本文的在线版本（doi：10.1038/nmeth.2642）包含补充材料，可供授权用户使用。IntOGen-mutations平台（http：//www.intogen.org/mutations/）总结了肿瘤发生中涉及的体细胞突变、基因和途径。它识别和可视化癌症驱动因素，分析来自13个癌症部位的4，623个外显子。它为癌症研究人员提供支持，帮助识别肿瘤队列中的驱动因素，并帮助对突变进行排名，以更好地做出临床决策。本文的在线版本（doi：10.1038/nmeth.2642）包含补充材料，可供授权用户使用。
IntOGen-mutations is a discovery tool for cancer researchers to find driver mutations in genes and pathways. The online version of this article (doi:10.1038/nmeth.2642) contains supplementary material, which is available to authorized users. The IntOGen-mutations platform (http://www.intogen.org/mutations/) summarizes somatic mutations, genes and pathways involved in tumorigenesis. It identifies and visualizes cancer drivers, analyzing 4,623 exomes from 13 cancer sites. It provides support to cancer researchers, aids the identification of drivers across tumor cohorts and helps rank mutations for better clinical decision-making. The online version of this article (doi:10.1038/nmeth.2642) contains supplementary material, which is available to authorized users.
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影响因子：
64.8
作者：
Ellis, Matthew J.;Ding, Li;Shen, Dong;Luo, Jingqin;Suman, Vera J.;Wallis, John W.;Van Tine, Brian A.;Hoog, Jeremy;Goiffon, Reece J.;Goldstein, Theodore C.;Ng, Sam;Lin, Li;Crowder, Robert;Snider, Jacqueline;Ballman, Karla;Weber, Jason;Chen, Ken;Koboldt, Daniel C.;Kandoth, Cyriac;Schierding, William S.;McMichael, Joshua F.;Miller, Christopher A.;Lu, Charles;Harris, Christopher C.;McLellan, Michael D.;Wendl, Michael C.;DeSchryver, Katherine;Allred, D. Craig;Esserman, Laura;Unzeitig, Gary;Margenthaler, Julie;Babiera, G. V.;Marcom, P. Kelly;Guenther, J. M.;Leitch, Marilyn;Hunt, Kelly;Olson, John;Tao, Yu;Maher, Christopher A.;Fulton, Lucinda L.;Fulton, Robert S.;Harrison, Michelle;Oberkfell, Ben;Du, Feiyu;Demeter, Ryan;Vickery, Tammi L.;Elhammali, Adnan;Piwnica-Worms, Helen;McDonald, Sandra;Watson, Mark;Dooling, David J.;Ota, David;Chang, Li-Wei;Bose, Ron;Ley, Timothy J.;Piwnica-Worms, David;Stuart, Joshua M.;Wilson, Richard K.;Mardis, Elaine R.
通讯作者：
Mardis, Elaine R.
影响因子：
14.9
作者：
Gonzalez-Perez A;Lopez-Bigas N
通讯作者：
Lopez-Bigas N
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.8
作者：
Kumar, Prateek;Henikoff, Steven;Ng, Pauline C.
通讯作者：
Ng, Pauline C.
影响因子：
30.8
作者：
Weinstein, John N.;Collisson, Eric A.;Mills, Gordon B.;Shaw, Kenna R. Mills;Ozenberger, Brad A.;Ellrott, Kyle;Shmulevich, Ilya;Sander, Chris;Stuart, Joshua M.
通讯作者：
Stuart, Joshua M.