Contemporary Understanding of miRNA-Based Regulation of Secondary Metabolites Biosynthesis in Plants.
Contemporary Understanding of miRNA-Based Regulation of Secondary Metabolites Biosynthesis in Plants.
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DOI：
10.3389/fpls.2017.00374
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发表时间：
2017
影响因子：
5.6
通讯作者：
Dahuja A
中科院分区：
文献类型：
--
作者：
Gupta OP;Karkute SG;Banerjee S;Meena NL;Dahuja A
植物的次生代谢产物，如黄酮类、萜类和生物碱等，因其对植物各种病虫害的防御作用和对人类的药用价值而广为人知。由于这些植物化学物质具有巨大的生物学意义，了解它们的生物合成途径的调节是至关重要的。近年来，分子技术的进步使我们能够更好地了解次生代谢物生物合成途径中涉及的蛋白质、酶、基因等。MiRNAs是一种神奇的、微小的、非编码的核苷酸，在真核生物中发挥着基因表达的关键调节作用。尽管已经积累了miRNA介导的几个过程的调控知识，但miRNAs参与调控植物次生产物的生物合成仍然知之甚少。在这里，我们总结了最近在miRNAs的鉴定和特性方面取得的进展，这些miRNAs参与调节植物次生代谢物的生物合成，并讨论了未来为其靶向操作设计可行的策略的前景。
Plant's secondary metabolites such as flavonoids, terpenoids, and alkaloids etc. are known for their role in the defense against various insects-pests of plants and for medicinal benefits in human. Due to the immense biological importance of these phytochemicals, understanding the regulation of their biosynthetic pathway is crucial. In the recent past, advancement in the molecular technologies has enabled us to better understand the proteins, enzymes, genes, etc. involved in the biosynthetic pathway of the secondary metabolites. miRNAs are magical, tiny, non-coding ribonucleotides that function as critical regulators of gene expression in eukaryotes. Despite the accumulated knowledge of the miRNA-mediated regulation of several processes, the involvement of miRNAs in regulating secondary plant product biosynthesis is still poorly understood. Here, we summarize the recent progress made in the area of identification and characterizations of miRNAs involved in regulating the biosynthesis of secondary metabolites in plants and discuss the future perspectives for designing the viable strategies for their targeted manipulation.