Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials.
Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials.
复制标题
DOI：
10.1002/wnan.1333
复制
发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Lefebvre DE
中科院分区：
文献类型：
--
作者：
Bellmann S;Carlander D;Fasano A;Momcilovic D;Scimeca JA;Waldman WJ;Gombau L;Tsytsikova L;Canady R;Pereira DI;Lefebvre DE
食物中的许多天然化学物质都在纳米尺寸范围内，胃肠道（GI）对纳米尺寸营养素的选择性吸收是正常的生理过程。新型工程纳米材料（NM）可以为食品带来各种好处，例如，增强营养。评估潜在风险需要了解这些实体在GI管腔中的稳定性，并了解它们是否可以被吸收，从而成为全身可用的。关于哺乳动物体内吸收工程NM的数据正在出现，这些NM由具有一系列特性的化学品组成，包括金属、矿物质、生化大分子和脂质基实体。体外和计算机模拟流体孵育数据也提供了与胃肠道中存在的管腔因子相互作用后颗粒稳定性、聚集和表面性质变化的一些证据。这些变量包括物理力、渗透浓度、pH值、消化酶、其他食物、内源性生化物质和肠道微生物。需要进一步的研究来填补这些参数对NM完整性、理化性质和GI吸收的影响的剩余数据空白。在开发胃肠道模型以量化食品相关工程NM的吸收百分比以进行风险评估时，了解最具影响力的管腔参数至关重要。WIREs Nanomed Nanobiotechnol 2015，7：609-622. doi：10.1002/wnan.1333有关本文的更多资源，请访问WIREs网站。
Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid‐based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food‐relevant engineered NMs for risk assessment. WIREs Nanomed Nanobiotechnol 2015, 7:609–622. doi: 10.1002/wnan.1333 For further resources related to this article, please visit the WIREs website.