RELATIVE ABUSE LIABILITY OF DIAZEPAM AND OXAZEPAM - BEHAVIORAL AND SUBJECTIVE DOSE EFFECTS
RELATIVE ABUSE LIABILITY OF DIAZEPAM AND OXAZEPAM - BEHAVIORAL AND SUBJECTIVE DOSE EFFECTS
复制标题
DOI：
10.1007/bf00427437
复制
发表时间：
1984-01-01
影响因子：
3.4
通讯作者：
ROACHE, JD
中科院分区：
文献类型：
--
作者：
GRIFFITHS, RR;MCLEOD, DR;ROACHE, JD
在有药物滥用史的志愿者中研究了地西泮（10-160 mg）和奥沙西泮（30-480 mg）的作用。在双盲和平衡条件下，每3天口服给药一次。时间-作用曲线下面积数据（AUC）的剂量效应显示，地西泮在各种精神、认知、工作人员评定和主观测量方面的效力是奥沙西泮的2.6-5.7倍。相对效力的比较表明，地西泮是相对更有效地产生喜欢比产生精神和认知的影响。地西泮产生更大的峰值效应比奥沙西泮对一些工作人员和受试者的评价措施，包括喜欢。与奥沙西泮相比，地西泮起效更快，达到最大效应的时间更短（1-2 h vs. 4- 1 - 2 h），而两种药物的效应抵消时间相似。地西泮被归类为产生巴比妥类主观效应（38.3%）的频率高于奥沙西泮（13.8%），而奥沙西泮被确定为安慰剂的频率高于地西泮。160 mg地西泮和480 mg奥沙西泮重复给药显示，地西泮的AUC喜好性大于奥沙西泮，奥沙西泮对精神和认知效应产生耐受性，但地西泮未产生耐受性。这项研究表明，地西泮可能比奥沙西泮有更高的滥用倾向。
The effects of diazepam (10-160 mg) and oxazepam (30-480 mg) were studied in volunteers with histories of drug abuse. Oral doses were administered every 3rd day under double-blind and counterbalanced conditions. Dose-effects with area under the time-action curve data (AUC) showed diazepam to be 2.6-5.7 times more potent than oxazepam on various psychomotor, cognitive, staff-rated and subjective measures. Comparison of relative potencies showed diazepam to be relatively more potent in producing liking than in producing psychomotor and cognitive effects. Diazepam produced greater peak effects than oxazepam on a number of staff- and subject-rated measures, including liking. Onset of effect was more rapid and time to maximal effect was shorter (1-2 h vs. 4-12 h) with diazepam than oxazepam, while time to offset of effect was similar for the 2 drugs. Diazepam was categorized as producing barbiturate-like subjective effects (38.3%) more frequently than was oxazepam (13.8%), while oxazepam was identified as placebo more often than diazepam. Repeated administration of 160 mg diazepam and 480 mg oxazepam showed that AUC liking was greater for diazepam than oxazepam, and that tolerance to psychomotor and cognitive effects occurred with oxazepam, but not diazepam. This study suggests that diazepam may have a higher abuse liability than oxazepam.