Polymeric micelles based on amphiphilic scorpion-like macromolecules: Novel carriers for water-insoluble drugs
Polymeric micelles based on amphiphilic scorpion-like macromolecules: Novel carriers for water-insoluble drugs
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DOI：
10.1007/s11095-004-9005-3
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发表时间：
2005-01-01
影响因子：
3.7
通讯作者：
Uhrich, KE
中科院分区：
文献类型：
--
作者：
Djordjevic, J;Barch, M;Uhrich, KE
目的.目的是评估两亲性蝎状大分子（AScMs）作为疏水性药物的药物载体。用O/W乳化法将吲哚美辛（IMC）包合到两种ASCM胶束（M12 P5和M12 P2）中。考察了IMC与聚合物的投料比、亲水嵌段分子量对胶束粒径、IMC包封率和释放行为的影响。用人脐静脉内皮细胞（HUVEC）检测AScMs的细胞毒性。当吲哚美辛：聚合物的比例为0.1：1时，M12 P5和M12 P2胶束中IMC的包封率最高（分别为72.3和20.2%）。负载IMC的M12 P5和M12 P2聚合物胶束的尺寸为
Purpose. The objective was to evaluate amphiphilic scorpion-like macromolecules (AScMs) as drug carriers for hydrophobic drugs.Methods. Indomethacin (IMC) was incorporated into two AScM micelleS (M12P5 and M12P2) by the O/W emulsion technique. The influences of IMC:polymer feed ratio and molecular weight of the hydrophilic block of AScMs on the micelle size, IMC entrapment efficiency and release behavior were investigated. Furthermore, cytotoxicity of the AScMs was evaluated with human umbilical vein endothelial cells (HUVEC).Results. The maximal IMC entrapment efficiency in M12P5 and M12P2 micelles (72.3 and 20.2%, respectively) was obtained at ratios of 0.1 to 1 for indomethacin:polymer. The sizes of IMC-loaded M12P5 and M12P2 polymeric micelles were