Posterior subtenon triamcinolone acetonide for refractory diabetic macular edema
Posterior subtenon triamcinolone acetonide for refractory diabetic macular edema
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DOI：
10.1016/j.ajo.2004.09.038
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发表时间：
2005-02-01
影响因子：
4.2
通讯作者：
Kaiser, PK
中科院分区：
文献类型：
--
作者：
Bakri, SJ;Kaiser, PK
目得：目的：评价后筋膜下注射曲安奈德治疗难治性糖尿病性黄斑水肿（DME）的疗效。设计：回顾性、干预性、病例系列。患者人群：在一次或多次局灶性黄斑光凝治疗后3个月或3个月以上累及中央凹中心的持续性临床显著DME患者纳入研究。排除标准为皮质类固醇史、反应性眼内压（lop）升高、3个月内眼内手术和1个月内任何激光治疗。程序：所有患者均接受了眼科病史和检查，包括最佳矫正Snellen视力、IOP测量、眼前节检查（包括根据LOCS II标准评价透镜状态）、散瞳眼底检查和基线时后Tenon下注射40 mg曲安奈德。在注射后1、3、6和12个月对患者进行重新评估。平均基线视力为20/80。平均视力在1个月时显著改善至20/50，然后在3个月时稳定至20/65，在6个月时稳定至20/68，在12个月时稳定至20/63。并发症是罕见的，在3-montb评价和两个patients.Conclusions：视力保持稳定或改善后12个月的时间后，Tenon曲安奈德注射难治性DME眼内压的短暂显着上升。在1个月时，视力有统计学显著改善。
PURPOSE: To evaluate posterior subtenon injection of triamcinolone acetonide for refractory diabetic macular edema (DME).DESIGN: Retrospective, interventional, case series.METHODS: SETTING: Clinical practice. PATIENT POPULATION: Patients with persistent clinically significant DME involving the center of the fovea 3 or more months after one or more treatments of focal macular photocoagulation were included. Exclusion criteria were a history of corticosteroid,responsive intraocular pressure (lop) rise, intraocular surgery within 3 months, and any laser treatment within I month. PROCEDURE: All patients received an ophthalmic history and examination including best-corrected Snellen visual acuity, IOP measurement, anterior segment examination including evaluation of lens status with LOCS II criteria, dilated fundus examination, and a posterior subtenon injection of 40 mg triamcinolone acetonide at baseline. Patients were reevaluated at 1, 3, 6, and 12 months after injection.RESULTS: Seventy-three injections were performed in 63 eyes of 50 patients. The mean baseline visual acuity was 20/80. Mean visual acuity significantly improved to 20/50 at 1 month, then stabilized to 20/65 at 3 months 20/68 at 6 months, and 20/63 at 12 months. Complications were rare, with a transient significant rise in intraocular pressure at the 3-montb evaluation and ptosis in two patients.CONCLUSIONS: Visual acuities remained stable or improved over a 12-month period after posterior sub, tenon triamcinolone injections for refractory DME. There was a statistically significant improvement in visual acuity at 1 month.