Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion.
Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion.
复制标题
生长激素分泌素和生长抑素在调节生长激素分泌中的生理作用。
DOI：
10.1016/0006-291x(82)91758-2
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发表时间：
1982
影响因子：
3.1
通讯作者：
Guillemin,R
中科院分区：
文献类型：
--
作者：
Wehrenberg,WB;Ling,N;Böhlen,P;Esch,F;Brazeau,P;Guillemin,R
生长激素分泌素是一种 44 个氨基酸的肽，在麻醉大鼠中具有有效的生长激素 (GH) 释放活性，并在有意识的自由活动大鼠中进行了测试。当在自发 GH 脉冲之间随机时间施用 (iv) 1 至 10 μg 的高剂量时，反应不一致。当在相同条件下测试相似剂量但在用生长抑素抗体预处理的大鼠中时，所有动物均表现出血浆 GH 显着且立即增加 5 至 10 倍。类似地，当对禁食 72 小时的大鼠施用 1 μg 剂量的生长激素分泌素时，也无法有效增加血浆 GH，这是已知增强内源性生长抑素分泌的范例。然而，如果大鼠接受生长抑素抗体预处理，血浆 GH 会增加 20 倍以上。这些结果证明了生长激素分泌素和生长抑素在调节 GH 分泌中发挥动态和相反的作用。
Somatocrinin, a 44 amino acid peptide with potent growth hormone (GH) releasing activity in anesthetized rats, was tested in conscious freely-moving rats. When high doses of 1 to 10 μg were administered (iv) at random times between spontaneous GH pulses, the responses were inconsistent. When similar doses were tested under identical conditions but in rats pretreated with antibodies against somatostatin, all animals demonstrated a marked and immediate increase in plasma GH of 5 to 10 fold. Similarly, a 1 μg dose of somatocrinin was also ineffective in increasing plasma GH when administered to rats subjected to a 72 h fast, a paradigm known to enhance endogenous somatostatin secretion. However, plasma GH increased over 20 fold if rats were pretreated with antibodies against somatostatin. These results demonstrate the dynamic and opposite roles exerted by somatocrinin and somatostatin in regulating GH secretion.