The size and fiber composition of the anterior commissure with respect to gender and schizophrenia
The size and fiber composition of the anterior commissure with respect to gender and schizophrenia
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DOI：
10.1016/s0006-3223(98)00323-0
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发表时间：
1999-05-01
影响因子：
10.6
通讯作者：
Crow, TJ
中科院分区：
文献类型：
--
作者：
Highley, JR;Esiri, MM;Crow, TJ
背景：本研究根据精神分裂症的非对称性偏斜及其解剖改变的证据，对14例女性对照组、15例男性对照组、15例女性精神分裂症患者、15例男性精神分裂症患者的尸脑前连合进行了测量。此外，采用Palmgren银染法和体视学方法测量了一组病例(n=10名女性对照组，10名男性对照组，8名女性精神分裂症患者，9名男性精神分裂症患者)的纤维密度和纤维数量。结果：在对照组中，女性的纤维数量多于男性(p=.024)。在精神分裂症患者中，横截面积没有受到影响，但纤维密度存在显著的性别X诊断交互作用(p=0.026)，对应于女性患者的减少，但男性患者没有。结论：精神分裂症患者前连合纤维密度的减少与大脑半球间连通性的改变是一致的，但这一发现仅限于女性，强调了性别与理解大脑半球相互作用的本质的相关性。(C)1999年生物精神病学学会。
Background: In light of evidence for deviations in asymmetry and alterations in the anatomy of the corpus callosum in schizophrenia, this study examined the anterior commissure in post mortem brains (n = 14 female control patients, 15 male control patients, II female schizophrenic patients, 15 male schizophrenic patients).Methods: Measures were made of the cross-sectional area of the anterior commissure in the midsagittal plane. In addition, the fiber density and fiber number were measured in a subset of cases (n = 10 female control subjects, 10 male control subjects, 8 female schizophrenic patients, 9 male schizophrenic patients), using the Palmgren silver stain and stereological methods.Results: In control subjects, fiber numbers were greater (p =.024) in women than men. In schizophrenia, the cross-sectional area was unaffected but for fiber density there was a significant gender X diagnosis interaction (p =.026), corresponding to a reduction in female, but nor male patients with schizophrenia.Conclusions: The reduction in density of fibers in the anterior commissure is consistent with an alteration of interhemispheric connectivity in schizophrenia, but the restriction of the finding to women emphasizes the relevance of gender to understanding the nature of the hemispheric interaction. (C) 1999 Society of Biological Psychiatry.