Expression and function of C1q receptors and C1q binding proteins at the cell surface.
Expression and function of C1q receptors and C1q binding proteins at the cell surface.
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DOI：
10.1078/0171-2985-00142
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发表时间：
2002
期刊：
影响因子：
2.8
通讯作者：
I. Ghiran;S. Tyagi;L. Klickstein;A. Nicholson‐Weller
中科院分区：
文献类型：
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作者：
I. Ghiran;S. Tyagi;L. Klickstein;A. Nicholson‐Weller
C1q是补体的第一组分的识别单元，其不仅结合含有免疫复合物的IgG和IgM，而且还识别外来结构如内毒素的脂质A和在凋亡细胞表面表达的分子。在这篇综述中，质膜受体和C1q的结合蛋白进行了讨论，并提出了新的数据钙网蛋白在人外周血细胞的表达。尽管对C1q受体和结合分子了解很多，但关于它们在体内的作用仍有许多问题。
C1q is the recognition unit of the first component of complement that binds not only IgG and IgM containing immune complexes, but also recognizes foreign structures such as the lipid A of endotoxin, and molecules expressed at the surface of apoptotic cells. In this review, the plasma membrane receptors and binding proteins for C1q are discussed and new data are presented on calreticulin expression on human peripheral blood cells. Although much is known about C1q receptors and binding molecules there are still many questions regarding their role in vivo.