Effects of acute increases in plasma osmolality on plasma vasopressin-associated neurophysin in conscious rats: implications for osmoregulation.
Effects of acute increases in plasma osmolality on plasma vasopressin-associated neurophysin in conscious rats: implications for osmoregulation.
复制标题
血浆渗透压急剧增加对清醒大鼠血浆加压素相关神经素的影响：对渗透压调节的影响。
DOI：
10.1159/000124099
复制
发表时间：
1985
影响因子：
4.1
通讯作者：
North,WG
中科院分区：
文献类型：
--
作者：
Cheng,SW;North,WG
在清醒、慢性插管的Long-Evans大鼠上，研究了静脉输注18%生理盐水、25%甘露醇、15%甘露醇和1.35%生理盐水对下丘脑-神经-垂体系统的反应。18%生理盐水和25%甘露醇对血浆渗透压(POSM)和血浆血管加压素相关神经生理蛋白浓度([VP-RNP])的影响相似。正如预期的那样，18%生理盐水处理的动物的血浆钠浓度([Na+])显著升高，而25%甘露醇处理的动物的血浆钠浓度显著降低。注射甘露醇可显著减轻体重。两组Δ[Vp-RnP]与ΔPosm之间的斜率几乎相同。联合输注15%甘露醇和1.35%生理盐水可引起与其他两种输注方案相当的Posm升高，但[Vp-Δ]的升高幅度较小，[Vp-RNP]与ΔPosm之间的关系斜率约为18%生理盐水或25%甘露醇组的一半。这种组合也使[Na+]保持在接近正常水平，在这些动物中，体重的下降明显小于那些接受25%甘露醇的大鼠。这项研究的结果表明，渗透压受体和/或钠受体以外的其他因素参与了在急性输注高渗溶液时引起神经垂体原理的释放。
We studied the responses of the hypothalamo-neurohypophysial system to intravenous infusions of 18% saline, 25% mannitol and a combination of 15% mannitol and 1.35% saline in conscious, chronically catheterized Long-Evans rats. Infusions of 18% saline and 25% mannitol produced similar increases in plasma osmolality (Posm) and plasma vasopressin-associated neurophysin concentration ([VP-RNP]). As expected, plasma sodium concentration ([Na+]) for the 18% saline-treated animals was significantly elevated while that for the 25% mannitol-treated animals was significantly reduced. Mannitol infusion caused a significantly greater loss of body weight. The slopes of the relationship between Δ[VP-RNP] and ΔPosmwere almost identical for the two groups. Infusion of a combination of 15% mannitol and 1.35% saline produced a rise in Posmcomparable to that observed for the other two infusion regimens, but caused smaller increases in [VP-RNP], the slope of the relationship between Δ[VP-RNP] and ΔPosmbeing about half of those for the infusion with 18% saline or 25% mannitol. This combination also maintained [Na+] close to normal levels and in these animals there was a loss of body weight that was significantly smaller than that for those rats receiving 25% mannitol. The results of this study imply that factors other than osmoreceptors and/or sodium receptors are involved in causing a release of neurohypophysial principles during acute infusion of hypertonic solutions.