NEUROPATHOLOGIC AND CLINICAL-FEATURES OF PARKINSONS-DISEASE IN ALZHEIMERS-DISEASE PATIENTS
NEUROPATHOLOGIC AND CLINICAL-FEATURES OF PARKINSONS-DISEASE IN ALZHEIMERS-DISEASE PATIENTS
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DOI：
10.1212/wnl.37.5.754
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发表时间：
1987-05-01
期刊：
影响因子：
9.9
通讯作者：
MIRRA, SS
中科院分区：
文献类型：
--
作者：
DITTER, SM;MIRRA, SS
虽然帕金森氏病（PD）中的痴呆得到了很好的描述，但阿尔茨海默氏病（AD）中的PD特征正日益受到重视。在20例经神经病理学证实的AD脑中，11例（55%）显示PD改变（路易体形成、神经元丢失和色素核胶质增生），伴和不伴PD病理学的病例在年龄或症状持续时间方面无显著差异。在没有抗精神病药物治疗的情况下，80%的PD病理学患者有强直史，但只有14%的无PD病理学患者有强直史。两组均未观察到震颤。这表明在许多AD患者中观察到的锥体外系体征，特别是强直，与共存的PD病理学有关。
While dementia in Parkinson''s disease (PD) is well described, PD features in Alzheimer''s disease (AD) are being increasingly recognized. In 20 neuropathologically confirmed AD brains, 11 cases (55%) showed PD changes (Lewy body formation, neuronal loss, and gliosis of pigmented nuclei), with no significant difference in age or symptom duration between those cases with and without PD pathology. A history of rigidity in the absence of neuroleptic medication was noted in 80% of those with PD pathology but only 14% of those without PD pathology. Tremor was not observed in either group. This suggests that extrapyramidal signs, especially rigidity, noted in many AD patients are related to coexistent PD pathology.