Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.
Octopaminergic modulation of a fly visual motion-sensitive neuron during stimulation with naturalistic optic flow.
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DOI：
10.3389/fnbeh.2013.00155
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发表时间：
2013
影响因子：
3
通讯作者：
Kurtz R
中科院分区：
文献类型：
--
作者：
Rien D;Kern R;Kurtz R
在各种物种中，运动活动，如行走或飞行，已经被证明改变了视觉信息处理。神经调节剂章鱼胺被证明以类似于运动活动的方式改变苍蝇视觉系统中视流处理神经元的反应特征。这种调制导致神经元反应增强，特别是在高时间频率的持续刺激期间，并缩短了对模式运动突然开始的反应潜伏期。这些依赖于状态的变化被解释为调整神经元的调谐，以适应运动过程中遇到的高速范围。在这里，我们评估了这些变化对飞行中所经历的光流处理的意义。基于对Calliphora vicina在竞技场中飞行的头部位置和凝视方向的测量，重建了自然图像序列。我们记录了在全景刺激设备(FliMax)上呈现这些图像序列时V1神经元的反应。与以前的描述一致，我们发现章鱼胺激动剂可增加自发和刺激诱发的尖峰频率，而拮抗剂则可降低自发的尖峰频率。此外，对八胺能激活的反应潜伏期有一个微小但持续的减少，这可能支持对视流信号的快速反应，并限制闭环式视神经调节过程中的不稳定性。然而，除了这些影响之外，不同药物诱导状态下的动态反应特性之间的相似性令人惊讶地高，这表明自然视流的处理并没有从根本上被八胺能调节所改变。
In a variety of species locomotor activity, like walking or flying, has been demonstrated to alter visual information processing. The neuromodulator octopamine was shown to change the response characteristics of optic flow processing neurons in the fly's visual system in a similar way as locomotor activity. This modulation resulted in enhanced neuronal responses, in particular during sustained stimulation with high temporal frequencies, and in shorter latencies of responses to abrupt onsets of pattern motion. These state-dependent changes were interpreted to adjust neuronal tuning to the range of high velocities encountered during locomotion. Here we assess the significance of these changes for the processing of optic flow as experienced during flight. Naturalistic image sequences were reconstructed based on measurements of the head position and gaze direction of Calliphora vicina flying in an arena. We recorded the responses of the V1 neuron during presentation of these image sequences on a panoramic stimulus device (“FliMax”). Consistent with previous accounts, we found that spontaneous as well as stimulus-induced spike rates were increased by an octopamine agonist and decreased by an antagonist. Moreover, a small but consistent decrease in response latency upon octopaminergic activation was present, which might support fast responses to optic flow cues and limit instabilities during closed-loop optomotor regulation. However, apart from these effects the similarities between the dynamic response properties in the different pharmacologically induced states were surprisingly high, indicating that the processing of naturalistic optic flow is not fundamentally altered by octopaminergic modulation.
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