Twist expression in patients with cervical cancer is associated with poor disease outcome
Twist expression in patients with cervical cancer is associated with poor disease outcome
复制标题
DOI：
10.1093/annonc/mdm344
复制
发表时间：
2008-01-01
影响因子：
50.5
通讯作者：
Kikkawa, F.
中科院分区：
文献类型：
--
作者：
Shibata, K.;Kajiyama, H.;Kikkawa, F.
背景：Twist是一种基本的螺旋-环-螺旋转录因子，已被报道与人类癌症的发生和进展有关。我们观察Twist在宫颈癌中的分布和表达，探讨其临床意义。患者和方法：我们检测了101例宫颈癌标本中Twist的分布和表达，并确定了其表达与观察到的临床病理特征（包括患者预后）之间的关系。结果：101例标本中Twist免疫表达阴性55例，阳性46例。当被分为阴性和阳性表达时，Twist与所检查的任何临床病理参数无关。Twist阳性表达与阴性表达相比，可显著预测较差的总生存期（OS）和无进展生存期（PFS） （P < 0.01）。在多因素分析中，Twist阳性表达是OS的独立预后因素（P < 0.05）。结论：我们的数据表明，Twist阳性表达似乎是宫颈癌患者的一个有用的标志物，可能有不利的临床结果。
Background: Twist, a basic helix-loop-helix transcription factor, has been reported to be associated with the development and progression of human cancer. We examined the distribution and expression of Twist in cervical cancer to examine its clinical significance.Patients and methods: We examined the distribution and expression of Twist in 101 cervical cancer specimens and determined the association between their expression and the cliinico-pathological features observed, including patient outcome.Results: Of the 101 specimens, 55 cases were negative for Twist immuno-expression, whereas 46 were positive. When categorized into negative versus positive expression, Twist was not associated with any of the clinico-pathological parameters examined. Positive Twist expression significantly predicted poorer overall survival (OS) and progression-free survival (PFS) when compared with negative expression (P < 0.01). In the multivariate analyses, positive Twist expression was an independent prognostic factor for OS (P < 0.05).Conclusions: Our data imply that positive Twist expression seems to be a useful marker in patients with cervical cancer likely to have an unfavorable clinical outcome.