The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis.
The effect of chronic clozapine and haloperidol on basal dopamine release and metabolism in rat striatum and nucleus accumbens studied by in vivo microdialysis.
复制标题
通过体内微透析研究慢性氯氮平和氟哌啶醇对大鼠纹状体和伏核基础多巴胺释放和代谢的影响。
DOI：
10.1016/0014-2999(90)90033-3
复制
发表时间：
1990
影响因子：
5
通讯作者：
Meltzer,HY
中科院分区：
文献类型：
--
作者：
Ichikawa,J;Meltzer,HY
使用体内微透析在清醒、自由活动的大鼠的纹状体和伏核中研究氯氮平和氟哌啶醇长期治疗对基础多巴胺释放和代谢的影响。慢性氟哌啶醇（2 mg/kg × 21 天）但慢性氯氮平（20 mg/kg × 21 天）不会降低纹状体和伏隔核中的基础多巴胺释放和代谢。这些结果与先前报道的体内伏安法的结果显着不同。讨论了可能的解释。
The effects of chronic treatment with clozapine and haloperidol on basal dopamine release and metabolism were studied in the striatum and the nucleus accumbens of awake, freely moving rats using in vivo microdialysis. Chronic haloperidol (2 mg/kg × 21 days) but not chronic clozapine (20 mg/kg × 21 days) decreased basal dopamine release and metabolism in both the striatum and the nucleus accumbens. These results differ significantly from those previously reported with in vivo voltammetry. Possible explanations are discussed.