Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment.
Hydrocephalus after Subarachnoid Hemorrhage: Pathophysiology, Diagnosis, and Treatment.
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蛛网膜下腔出血后脑积水的病理生理学、诊断和治疗
DOI：
10.1155/2017/8584753
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发表时间：
2017
影响因子：
--
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Chen S;Luo J;Reis C;Manaenko A;Zhang J
脑积水（HCP）是蛛网膜下腔出血患者的常见并发症。本文综述了近年来HCP的研究进展，并对HCP的分子起源及SAH后HCP的诊断和治疗进展进行了讨论。炎症、细胞凋亡、自噬和氧化应激是导致HCP的重要原因，而转化生长因子、基质金属蛋白酶和铁等已知分子最终导致HCP纤维化和阻塞。HCP的潜在药物仍处于临床前状态，手术是最普遍和有效的治疗方法，尽管不同的手术方法有各自的风险，包括终板开窗术、脑室-腹膜分流术和腰-腹膜分流术。HCP仍然是一种不容忽视的疾病，即使有各种解决方案，医学界仍在试图了解和解决其发展的原因和方式，并相应地改善这些HCP患者的预后。
Hydrocephalus (HCP) is a common complication in patients with subarachnoid hemorrhage. In this review, we summarize the advanced research on HCP and discuss the understanding of the molecular originators of HCP and the development of diagnoses and remedies of HCP after SAH. It has been reported that inflammation, apoptosis, autophagy, and oxidative stress are the important causes of HCP, and well-known molecules including transforming growth factor, matrix metalloproteinases, and iron terminally lead to fibrosis and blockage of HCP. Potential medicines for HCP are still in preclinical status, and surgery is the most prevalent and efficient therapy, despite respective risks of different surgical methods, including lamina terminalis fenestration, ventricle-peritoneal shunting, and lumbar-peritoneal shunting. HCP remains an ailment that cannot be ignored and even with various solutions the medical community is still trying to understand and settle why and how it develops and accordingly improve the prognosis of these patients with HCP.