A Study of the Genetic Variability of Human Respiratory Syncytial Virus (HRSV) in Cambodia Reveals the Existence of a New HRSV Group B Genotype
A Study of the Genetic Variability of Human Respiratory Syncytial Virus (HRSV) in Cambodia Reveals the Existence of a New HRSV Group B Genotype
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DOI：
10.1128/jcm.01131-11
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发表时间：
2011-10-01
影响因子：
9.4
通讯作者：
Buchy, Philippe
中科院分区：
文献类型：
--
作者：
Arnott, Alicia;Vong, Sirenda;Buchy, Philippe
人类呼吸道合胞病毒(HRSV)是工业化国家5岁儿童因呼吸道疾病住院的主要原因，肺炎是全球5岁儿童死亡的主要原因。虽然第一次发现HRSV是在1956年，但预防性疫苗尚未开发出来。在这里，我们报告了第一个连续5年调查柬埔寨所有年龄段人群中HRSV的循环和遗传多样性的研究结果。各年龄段门诊和住院人群HRSV感染率相当，分别为9.5%和8.2%。感染在5岁的儿童中最常见，毛细支气管炎是同一年龄组中最常见的临床症状。HRSV的环流是季节性的，通常与每年7月至11月的雨季重合。属于A和B组的HRSV菌株被检测到具有相同的频率；然而，我们观察到主要的循环HRSV基因可能两年一次地转移。大多数B组HRSV毒株属于最近报道的BA基因，但有10株被归类为新的B组HRSV基因SAB4，这是首次报道的。
Human respiratory syncytial virus (HRSV) is the leading cause of hospitalization of children aged < 5 years due to respiratory illness in industrialized countries, and pneumonia is the leading cause of mortality among children aged < 5 years worldwide. Although HRSV was first identified in 1956, a preventative vaccine has yet to be developed. Here we report the results of the first study to investigate the circulation and genetic diversity of HRSV in Cambodia among an all-ages population over 5 consecutive years. The incidences of HRSV infection among all-ages outpatient and hospitalized populations were equivalent, at 9.5% and 8.2%, respectively. Infection was most prevalent among children aged < 5 years, with bronchiolitis being the most frequently observed clinical syndrome in the same age group. Circulation of HRSV was seasonal, typically coinciding with the rainy season between July and November annually. Strains belonging to HRSV groups A and B were detected with equivalent frequencies; however, we observed a potentially biennial shift in the predominant circulating HRSV genotype. The majority of HRSV group B strains belonged to the recently described BA genotype, with the exception of 10 strains classified as belonging to a novel HRSV group B genotype, SAB4, first reported here.