Short-term Impact of Ambient Air Pollution and Air Temperature on Blood Pressure Among Pregnant Women
Short-term Impact of Ambient Air Pollution and Air Temperature on Blood Pressure Among Pregnant Women
复制标题
DOI：
10.1097/ede.0b013e318226e8d6
复制
发表时间：
2011-09-01
期刊：
影响因子：
5.4
通讯作者：
Slama, Remy
中科院分区：
文献类型：
--
作者：
Hampel, Regina;Lepeule, Johanna;Slama, Remy
背景：流行病学研究报告了空气污染水平与血压（BP）之间关系的不一致的发现，这主要是在老年人中进行的研究。空气污染对BP的短期影响尚未在孕妇中进行调查，孕妇可能是一个易感人群。方法：2002年至2006年间，在法国南希和普瓦捷进行的一项母婴队列研究中，1500名孕妇接受了11,220次重复血压测量（平均7.5次/名）。在固定监测点每小时测量一次二氧化氮（NO2）、空气动力学直径小于10 μ m的颗粒物（PM10）和气象变量。我们利用混合模式研究了BP与大气污染和温度的短期变化的关系。结果：温度降低10℃导致收缩压升高0.5%（95%置信区间= 0.1% ~ 1.0%）。测量血压前1天、5天和平均7天no2水平升高与收缩压降低有关。NO2浓度每增加11 μ g/m(3)， 7天平均NO2浓度下降幅度最大（-0.4%[-0.7%至-0.2%]）。PM10对收缩压的影响根据妊娠三个月的不同而不同：PM10浓度与妊娠早期收缩压升高和妊娠后期收缩压降低有关。结论：我们观察到空气污染和温度与孕妇血压的短期关联。这种血压变化是否具有临床意义还有待研究。（流行病学2011；22:671-679）
Background: Epidemiologic studies have reported inconsistent findings for the association between air pollution levels and blood pressure (BP), which has been studied mainly in elderly subjects. Short-term air pollution effects on BP have not been investigated in pregnant women, who may constitute a vulnerable population.Methods: Between 2002 and 2006, 1500 pregnant women from a mother-child cohort study conducted in Nancy and Poitiers, France, underwent 11,220 repeated BP measurements (average, 7.5 measurements/woman). Nitrogen dioxide (NO2), particulate matter with an aerodynamic diameter below 10 mu m (PM10), and meteorologic variables were measured on an hourly basis at permanent monitoring sites. We studied changes of BP in relation to short-term variations of air pollution and temperature with mixed models adjusted for meteorologic and personal characteristics.Results: A 10 degrees C decrease in temperature led to an increase in systolic BP of 0.5% (95% confidence interval = 0.1% to 1.0%). Elevated NO2-levels 1 day, 5 days and averaged over 7 days before the BP measurement were associated with reduced systolic BP. The strongest decrease was observed for the 7-day NO2 average (-0.4% [-0.7% to -0.2%] change for an 11 mu g/m(3) increase in NO2). PM10 effects on systolic BP differed according to pregnancy trimester: PM10 concentration was associated with systolic BP increases during the first trimester and systolic BP decreases later in pregnancy.Conclusions: We observed short-term associations of air pollution and of temperature with BP in pregnant women. Whether such changes in BP have clinical implications remains to be investigated. (Epidemiology 2011; 22: 671-679)