Etiology of surface light scattering on hydrophobic acrylic intraocular lenses
Etiology of surface light scattering on hydrophobic acrylic intraocular lenses
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DOI：
10.1016/j.jcrs.2012.05.043
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发表时间：
2012-10-01
影响因子：
2.8
通讯作者：
Karakelle, Mutlu
中科院分区：
文献类型：
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作者：
Ong, Marcia D.;Callaghan, Thomas A.;Karakelle, Mutlu
目得：研究疏水性丙烯酸人工晶状体（IOL）表面光散射的病因。单位：Alcon研究实验室，沃斯堡，得克萨斯州，美国。设计：实验研究。方法：人工晶状体从临床标本（n = 5），人尸体（n = 8），和成品库存（对照）。在定量和去除蛋白质之前和之后，测量表面光散射并对处于各种水合状态（干燥、短期润湿和长期水合）的IOL进行成像。选择的IOL样品进行了分析，X射线光电子能谱，扫描电子显微镜（SEM）与能量色散X射线分析，傅里叶变换红外光谱与衰减全反射，和低温SEM与聚焦离子beam.Results：没有无机沉积物或有机变化观察到任何IOL表面。在临床相关的水合条件下，表面光散射强度与蛋白质生物膜状态无关（P >= 0.11）。相反，IOL的水合状态显著地促进了表面光散射的强度（P
PURPOSE: To study the etiology of surface light scattering on hydrophobic acrylic intraocular lenses (IOLs).SETTING: Alcon Research Laboratories, Fort Worth, Texas, USA.DESIGN: Experimental study.METHODS: lntraocular lenses were obtained from clinical explantations (n = 5), from human cadavers (n = 8), and from finished-goods inventory (controls). Surface light scattering was measured and imaged with the IOLs in various hydration states (dry, short-term wetted, and long-term hydrated) before and after proteins were quantified and removed. Selected IOL samples were analyzed with x-ray photoelectron spectroscopy, scanning electron microscopy (SEM) with energy-dispersion x-ray analysis, Fourier-transform infrared spectroscopy with attenuated total reflectance, and cryogenic SEM with a focused ion beam.RESULTS: No inorganic deposits or organic changes were observed on any IOL surface. Under clinically relevant hydrated conditions, surface light-scattering intensity was independent of proteinaceous biofilm state (P >= .11). Instead, the hydration state of the IOLs significantly contributed to the intensity of surface light scattering (P