INTERSPECIES VARIATION OF COMPRESSIVE BIOMECHANICAL PROPERTIES OF THE MENISCUS
INTERSPECIES VARIATION OF COMPRESSIVE BIOMECHANICAL PROPERTIES OF THE MENISCUS
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DOI：
10.1002/jbm.820290706
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发表时间：
1995-07-01
期刊：
影响因子：
--
通讯作者：
WOO, SLY
中科院分区：
文献类型：
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作者：
JOSHI, MD;SUH, JK;WOO, SLY
各种动物模型已被用于研究膝关节半月板的正常和修复特性。然而，只有有限的数据，各种动物的骨骼生物力学性能。因此，本研究的目的是比较6个种属（人、牛、猴、犬、羊和猪）之间的股骨生物力学特性测量值。对厚度为1 mm、直径为4 mm的圆盘进行了单轴侧限压缩试验，得到了圆盘的粘弹性蠕变变形。两个生物力学参数，聚集体模量（H-A）和渗透性（卡帕），发现通过实施线性双相理论和一个新开发的非线性回归方案。沿着Student-Newman-Keuls比较检验进行单因素方差分析，以评估种属间这些参数的差异。绵羊大肠杆菌表现出与人类大肠杆菌最相似的H-A和kappa值。还测量了每个样本的含水量，并与kappa显著相关。在膝关节半月板材料特性中发现的种间差异表明，从动物模型中推断人类半月板生物力学行为数据时需要谨慎。(C)1995年，John Wiley and Sons，Inc.
Various animal models have been used to investigate the normal and reparative properties of the knee meniscus. Yet, only limited data on meniscal biomechanical properties of various animals are available. It was therefore the objective of this study to compare measurements of meniscal biomechanical properties between six species: human, bovine, monkey, canine, sheep, and porcine. Uniaxial confined compression tests were conducted on l-mm-thick, 4-mm-diameter meniscal discs, and the viscoelastic creep deformation was obtained. Two biomechanical parameters, the aggregate modulus (H-A) and permeability (kappa), were found by implementing the linear biphasic theory and a newly developed nonlinear regression scheme. A one-way analysis of variance was conducted along with Student-Newman-Keuls comparison tests to assess the differences in these parameters among the species. Sheep menisci exhibited H-A and kappa values most similar to human menisci. The water content of each specimen was also measured and correlated significantly with kappa. The interspecies variations found in material properties of the knee meniscus indicate the need for caution in extrapolating data on the biomechanical behavior of the human meniscus from animal models. (C) 1995 John Wiley and Sons, Inc.