Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes
Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes
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DOI：
10.1002/jgm.515
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发表时间：
2004-03
期刊：
影响因子：
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通讯作者：
S. Grosse;Y. Aron;Isabelle Honoré;G. Thévenot;C. Danel;A. Roche;M. Monsigny;I. Fajac
中科院分区：
文献类型：
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作者：
S. Grosse;Y. Aron;Isabelle Honoré;G. Thévenot;C. Danel;A. Roche;M. Monsigny;I. Fajac
由于我们之前已经证明，乳糖化聚乙烯亚胺是最有效的糖基化聚乙烯亚胺基因转移到原代培养的人呼吸道上皮细胞，我们在这里研究了乳糖残基在乳糖化聚乙烯亚胺在永生化细胞(ΣCFTE29o-细胞)和原代人呼吸道上皮细胞中观察到的提高基因转移效率的作用。
As we have previously shown that lactosylated polyethylenimine (PEI) is the most efficient glycosylated PEI for gene transfer into human airway epithelial cells in primary culture, we have studied here the role of the lactose residue in the enhancement of gene transfer efficiency observed with lactosylated PEI as compared with unsubstituted PEI in immortalized (ΣCFTE29o‐ cells) and primary human airway epithelial cells.