Genetic dissection of rhythmic motor networks in mice.
Genetic dissection of rhythmic motor networks in mice.
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DOI：
10.1016/b978-0-444-53613-6.00002-2
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发表时间：
2010
影响因子：
--
通讯作者：
Goulding, Martyn
中科院分区：
文献类型：
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作者：
Grossmann, Katja S.;Giraudin, Aurore;Britz, Olivier;Zhang, Jingming;Goulding, Martyn
简单的运动行为，如运动和呼吸，涉及有节奏和协调的肌肉运动，这些运动是由脊髓和后脑中的中央模式发生器（CPG）网络产生的。这些CPG网络产生可测量的行为输出，因此代表了研究神经系统用于产生特定行为的操作原理的理想模型系统。我们对控制神经元发育的转录密码的理解的最新进展为识别和靶向构成脊髓中运动CPG网络的不同神经元群体提供了一个切入点。这刺激了新的遗传方法的发展，以解剖和操纵脊髓和后脑中的神经网络。在这里，我们将讨论如何分子遗传学的出现，连同解剖和生理学方法已经开始彻底改变控制小鼠节律运动行为的神经元网络的研究。
Simple motor behaviors such as locomotion and respiration involve rhythmic and coordinated muscle movements that are generated by central pattern generator (CPG) networks in the spinal cord and hindbrain. These CPG networks produce measurable behavioral outputs, and thus represent ideal model systems for studying the operational principles that the nervous system uses to produce specific behaviors. Recent advances in our understanding of the transcriptional code that controls neuronal development have provided an entry point into identifying and targeting distinct neuronal populations that make up locomotor CPG networks in the spinal cord. This has spurred the development of new genetic approaches to dissect and manipulate neuronal networks both in the spinal cord and hindbrain. Here we discuss how the advent of molecular genetics together with anatomical and physiological methods has begun to revolutionize studies of the neuronal networks controlling rhythmic motor behaviors in mice.