T cell aging: a review of the transcriptional changes determined from genome-wide analysis.
T cell aging: a review of the transcriptional changes determined from genome-wide analysis.
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DOI：
10.3389/fimmu.2013.00121
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发表时间：
2013
影响因子：
7.3
通讯作者：
Weng NP
中科院分区：
文献类型：
--
作者：
Chen G;Lustig A;Weng NP
年龄对T细胞功能有不利影响。在过去的十年中，对衰老过程中T细胞基因组规模转录变化的分析已经产生了大量的数据，并提供了对衰老宿主T细胞基因表达变化以及随年龄积累的T细胞亚群的全局视图。本文就胸腺细胞和外周血成熟T细胞基因表达的变化，以及T细胞亚群随年龄增长的变化进行综述，并探讨T细胞中随年龄增长而改变的基因网络和信号通路。我们还讨论了进一步了解老年T细胞基因表达改变的分子基础的未来方向，这可能为基于基因的临床干预提供机会。
Age carries a detrimental impact on T cell function. In the past decade, analyses of the genome-scale transcriptional changes of T cells during aging have yielded a large amount of data and provided a global view of gene expression changes in T cells from aged hosts as well as subsets of T cells accumulated with age. Here, we aim to review the changes of gene expression in thymocytes and peripheral mature T cells, as well as the subsets of T cells accumulated with age, and discuss the gene networks and signaling pathways that are altered with aging in T cells. We also discuss future direction for furthering the understanding of the molecular basis of gene expression alterations in aged T cells, which could potentially provide opportunities for gene-based clinical interventions.