Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain
Members of the NF-κB family expressed in zones of active neurogenesis in the postnatal and adult mouse brain
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DOI：
10.1016/j.devbrainres.2004.10.010
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Grilli, M
中科院分区：
文献类型：
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作者：
Denis-Donini, S;Caprini, A;Grilli, M
ReL/NF-κ B转录因子家族参与细胞增殖、细胞死亡、细胞迁移和细胞相互作用。在这里，我们研究了免疫组织化学的表达模式，这个家庭的各种成员在出生后端脑发育和成年期，我们使用神经元和胶质细胞标记物，以确定他们表达的细胞类型。不同的Rel/NF-κ B蛋白在出生后在脑室下区和吻侧迁移流中高度表达。特别地，Rel A和p50在放射状神经胶质细胞、迁移神经元前体细胞和属于星形胶质细胞谱系的群体中表达。另一方面，Rel B仅在迁移神经元前体中表达，而c-Rel存在于位于吻侧迁移流边缘的少数细胞中。Rel A和p50的表达持续到成年期，特别是分别在脑室下区星形胶质细胞样细胞和迁移神经元前体中。NF-kappaB成员在出生后室管膜下区和吻侧迁移流中的选择性表达以及它们在正在进行的神经发生区域中持续到成年期，表明NF-kappaB表达与细胞增殖和迁移相关的可能机制。通过BrdU染色检测到它们存在于活跃增殖的祖细胞中，进一步表明NF-κ B可能是对神经发生重要的信号通路的一部分。(C)2004 Elsevier B. V.保留所有权利。
The ReL/NF-kappaB family of transcription factors is implicated in cell proliferation, cell death, cell migration and cell interactions. Here, we examined by immunohistochemistry the expression pattern of various members of this family during postnatal telencephalon development and during adulthood, and we used neuronal and glial markers to identify the cells types where they are expressed. Distinct Rel/NF-kappaB proteins are highly expressed postnatally in the subventricular zone and in the rostral migratory stream. In particular, Rel A and p50 are expressed in radial glial cells, in migrating neuron precursors and in a population belonging to the astrocytic lineage. Rel B, on the other hand, is only expressed in migrating neuron precursors, whereas c-Rel is present in a few cells located at the edges of the rostral migratory stream. The expression of Rel A and p50 persists into adulthood, particularly in subventricular zone astrocyte-like cells and in migrating neuron precursors, respectively. The selective expression of NF-kappaB members in the postnatal subventricular zone and rostral migratory stream and their persistence into adulthood in regions of ongoing neurogenesis suggests possible mechanisms linking NF-kappaB expression with cell proliferation and migration. Their presence in actively proliferating progenitor cells, detected by BrdU staining, further suggests that NF-kappaB may be part of a signaling pathway that is important for neurogenesis. (C) 2004 Elsevier B.V. All rights reserved.