Caudate nucleus dopamine D2 receptors in depressed suicide victims
Caudate nucleus dopamine D2 receptors in depressed suicide victims
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DOI：
10.1159/000054918
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发表时间：
2001-01-01
影响因子：
3.2
通讯作者：
Norlén, M
中科院分区：
文献类型：
--
作者：
Allard, P;Norlén, M
几条证据表明多巴胺系统参与了抑郁状态。在这项死后研究中，[H-3]雷氯必利与尾状核多巴胺D-2受体的结合在13名抑郁症自杀者和19名对照组中进行了研究。两组之间的B-max或K-d无差异。然而，由重度抑郁症患者组成的亚组的K-d值显著高于对照组。根据本研究，先前关于抑郁症中多巴胺代谢变化和多巴胺激动剂的抗抑郁作用的研究结果似乎不能通过抑郁症自杀受害者中多巴胺D-2受体密度或亲和力的改变来反映。版权所有（C）2001 S. Karger AG，巴塞尔。
Several lines of evidence indicate the involvement of the dopamine system in depressive states. In this post-mortem study, the binding of [H-3]raclopride to dopamine D-2 receptors in the caudate nucleus was investigated in 13 depressed suicide victims and 19 controls. There were no differences in B-max or K-d between the two groups. A subgroup consisting of individuals with major depression, however, had significantly higher K-d values than controls. Previous findings regarding changes in dopamine metabolism in depression and antidepressant effects of dopamine agonists seem, according to the present study, not to be reflected by alterations in density or affinity of dopamine D-2 receptors in depressed suicide victims. Copyright (C) 2001 S. Karger AG, Basel.