The emerging role of resident memory T cells in protective immunity and inflammatory disease.
The emerging role of resident memory T cells in protective immunity and inflammatory disease.
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DOI：
10.1038/nm.3883
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发表时间：
2015-07
期刊：
影响因子：
82.9
通讯作者：
Kupper TS
中科院分区：
文献类型：
--
作者：
Park CO;Kupper TS
在过去的十年里，有一件事变得很清楚，那就是存在于组织中的一个重要的记忆T细胞亚群--组织常驻记忆T细胞(TRM)。有一种新的认识是，TRM在人类组织特异性免疫和炎症性疾病中发挥作用。此外，在组织中维持TRM的分子信号的性质是许多研究的主题。此外，虽然TRM位于人类和小鼠与环境交界处的屏障组织中是合乎逻辑的，但在这两个物种的脑、肾、关节和其他非屏障组织中也发现了TRM。它们的生物学和行为使它们很可能在屏障和非屏障组织的慢性复发和缓解疾病中发挥作用。这篇综述将讨论最近对TRM生物学的理解，特别关注它们在疾病中的作用。
Over the past decade, it has become clear that there is an important subset of memory T cells that resides in tissues — tissue resident memory T cells (TRM). There is an emerging understanding that TRM have a role in human tissue specific immune and inflammatory diseases. Furthermore, the nature of the molecular signals that maintain TRM in tissues is the subject of much investigation. In addition while it is logical for TRM to be located in barrier tissues at interfaces with the environment in human and mouse, TRM have also been found in brain, kidney, joint, and other non-barrier tissues in both species. Their biology and behavior make it likely that they play a role in chronic relapsing and remitting diseases of both barrier and non-barrier tissues. This review will discuss recent understandings of the biology of TRM with a particular focus on their role in disease.