Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium
Efficacy and Safety of Praziquantel in Preschool-Aged Children in an Area Co-Endemic for Schistosoma mansoni and S. haematobium
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DOI：
10.1371/journal.pntd.0001917
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发表时间：
2012-12-01
影响因子：
3.8
通讯作者：
Utzinger, Juerg
中科院分区：
文献类型：
--
作者：
Coulibaly, Jean T.;N'Gbesso, Yve K.;Utzinger, Juerg
背景：在撒哈拉以南非洲，推荐的控制血吸虫病的策略是预防性化疗。重点是学龄儿童，但在高流行地区，学龄前儿童也有危险，因此可能需要吡喹酮治疗。由于儿科制剂（例如，糖浆）在埃及以外的地区不可用，使用粉碎的吡喹酮片剂，但这种治疗方案的有效性和安全性研究不足。
Background: In sub-Saharan Africa the recommended strategy to control schistosomiasis is preventive chemotherapy. Emphasis is placed on school-aged children, but in high endemicity areas, preschool-aged children are also at risk, and hence might need treatment with praziquantel. Since a pediatric formulation (e.g., syrup) is not available outside of Egypt, crushed praziquantel tablets are used, but the efficacy and safety of this treatment regimen is insufficiently studied.Methodology: We assessed the efficacy and safety of crushed praziquantel tablets among preschool-aged children (